Cognition Enhancing Supplements
Shopping Cart
Search Your Cart   Continue Shopping

Sunifiram

10mg Sunifiram Tablets :

Email to a Friend
12.99(15.72 €)
In Stock
Add to cart

Key Benefits

One of the only nootropics shown to enhance neuronal Long Term Potentiation (LTP)[2][3]

Shown to have ant-amnesic action via AMPA receptor, effectively reducing memory loss [4]

Has been shown to increase acetylcholine release: enhancing learning and memory [5]

 Effectively prevented chemically induced amnesia [5][6]

No toxic effects found even when the dose was increased by 1000 times [5] 



 Overview

Sunifiram (DM-235) or 1-benzoyl-4-propanoylpiperazine is an ampakine like alkaloid derived from pipirezine. It has been shown to be over 1000 time as potent as Piracetam,[1] only differing by having a piperazine backbone instead of the pyrrolidine. This means that Sunifiram is not technically a racetam nootropic, however, it bares very close resemblance in action and safety profile. Sunifiram is structurally related to other nootropics such as Sapunifiram (MN-19) and Unifiram. Sunifiram is able to enhance Long Term Potentiation (LTP), which is an extremely rare and powerful nootropic trait. As a strong Ampakine, Sunifiram is also able to enhance mental stimulation, increase alertness and attention, while also facilitating learning and memory via its acetylcholine releasing properties.


As a whole, the potency and varied cognitive enhancement offered by this nootropic make it a preferred and extremely popular new addition to the nootropic world.



Recommended Dosage

Take 1 tablet daily as required.

Each tablets contains exactly 10mg of Sunifiram. It is advised to start with a small 10mg dose. Sunifiram has been known to be extremely potent and doses of 20mg or higher can give notable stimulation much like caffeine or Adderall. Although one of the most potent nootropics available, Sunifiram is extremely non-toxic and has been shown to be completely safe even when the dose is 1000 times higher.

Details

Sunifiram demonstrates great potential as being one of the most powerful and stimulating nootropics.In particular the enhancement of Long term Potentiation (LTP); this is widely considered one of the most powerful and fundamental aspects of learning and memory, while being an interesting phenomena of neuronal plasticity. LTP is caused when two neurones are stimulated synchronously and fire at the same time causing a long-lasting enhancement in the signal transmission.

Although being equally as stimulating, Sunifiram has been reported to be similar in strength to Noopept but with more of a focus on memory rather than alertness. Sunifiram has been shown to increase NMDA-dependant signalling via the glycine binding site and increase AMPA receptor activation leading to its anti-amnesic effects. Further action upon the release of acetylcholine in prefrontal cortex shows its beneficial effect upon arousal, perception, attention and neuronal plasticity.[2][3][4]

Studies have shown a strong anti-amnesic affect after amnesia was induced chemically using scopolamine, baclofen, diphenhydramine, and clonidine.[5][6]

Pre-frontal release of acetylcholine has been observed after administration of Sunifiram. Acetylcholine is one of the key neurotransmitters involved in helping us to sustain attention and form new memories, while also pivotal to neuronal plasticity, arousal and reward systems.[7]

Sunifiram has been administered with an increase of 1000 times the dose with absolutely no toxicity observed. [5]
 

How Does Sunifiram Work?

Sunifiram has been shown to increase PKCα phosphorylation via the glycine binding site; effectively enhancing NMDA-dependant signalling.[3] Src is then actiated which in turn increases LTP. This NMDA-dependent LTP has been confirmed in vivo after 7 12 days oral dosage.[2] Phosphorilation of AMPAR via activation of CaMKII has also been noted. [3]

Mice with hippocampal dependent memory impairment, benefited from a diminished reduction in training sessions after administration of Sunifiram.[2]

Acetylcholine was found to be released from the prefrontal cortex of mice after Sunifiram injection. [5]

We are the UK's leading Sunifiram supplier. Experience the power of Sunifiram with Free UK shipping and Next Day option availble.








Cited+Sources


Customer reviews
 4/5
Sunifiram un po 'piccolo come avere Noopept, ma pi forte con sensazione visiva nel cervello, eccellente quando soleggiata.
 1/5
Does not work :(.
 3/5
Extremely effective.
 
Our products are not intended to diagnose, treat, cure or prevent any disease. We recommend consulting a medical practitioner before taking any of our products, especially those taking prescription medication and pregnant or lactating women. Long-term use of these products should be supervised and monitored by a health care professional. Any information presented on this website is not to be taken as, or in place of medical advice. The statements on this website have not been evaluated by the Food and Drug Administration. This is a food supplement and must not be used as a substitute for a varied and balanced diet and healthy lifestyle. Suitable for vegans and vegetarians. Please keep all products out of reach of children. Store in a cool, dark place out of direct sunlight.

Nootropics LTD is a company registered in England & Wales with company registration number: 07853205 and with VAT Registration number 174 2717 03 | Registered Office: Nootropics LTD, Demar House 14 Church Road,East Wittering,Chichester,West Sussex,PO20 8PS