We have seen very few nootropics with such a powerful action at such minute doses; as little as 5mg of Sunifiram is able to give an effect which far surpasses many older racetam like nootropics. The effect it is able to have on Long Term Potentiation has made it one of the key supplements for researchers interested in cognitive enhancement. LTP is one of the most interesting nootropic phenomenons as it can alter the brains synaptic plasticity which in turn is responsible for the ability of your synapses to strengthen or weaken in response to stimuli.
This is extremely important when the brain is under heavy loads as there must be some area for adaptation when cognitive processes are higher than usual. Noopept is one nootropic which has been compared with Sunifiram, as it shares a similar strength in dosage and is one of the new additions to the field. One impressive finding has showed, in animals, that even when the active amount of Sunifiram administered was increased to over 1000 times the normal amount, there was still no toxic effects to note.
However, the main difference between the two is that Sunifiram is able to improve awareness to a greater extent than Noopept, which tends to make the user more focused on a single task. One of the key benefits with Sunifiram is the acetylcholine release concentrated in the prefrontal cortex, which is able to influence attention, perception arousal and synaptic plasticity.
In one study the scientists were able to test the effectiveness of Sunifiram on amnesia which was artificially induced with scopolamine, clonidine and diphenhydramine. It was found that Sunifiram effectively reduced the amnesia to a statistically significant amount in these tests.
How Does Sunifiram Work?
The exact mechanism to explain how Sunifiram is able to have such a strong cognitive benefit is yet to be found, but scientist have identified some interesting models to show how some of these attributes may be better understood. One such mechanism is that of NMDA signaling which was confirmed after Sunifiram dosages were maintained for over 7 days.
This can explain some of the NMDA-dependent Long Term Potentiation seen with Sunifiram use. Further studies have shown rodents with memory impairment (centered around the hippocampus) benefitted from Sunifiram administration, when their ability to complete training sessions was measured. Finally, Sunifiram injections were able to cause the release of acetylcholine, which was detected in the prefrontal cortex of laboratory mice.