As a an extremely useful treatment for a condition more commonly referred to as Asthenia, Sulbutiamine is described to induce a state of mild stimulation, while helping to also improve general cognition and memory via an acetylcholine action. Alzheimer’s sufferers have also been able to benefit from the nootropics effects as these marked memory improvements have been significant, and can even be used in people suffering from schizophrenia.
Both objective recognition and operant conditional tests have shown improvements in animal studies after Sulbutiamine supplementation, this may be attributed to its ability to work on the bodies glutamatergic, cholinergic and reward pathways. Further studies have found memory boosts to also be attributed to these properties, with further examples of Sulbutiamine’s abilities to reduce the amnesia seen in schizophrenics.With regards to Alzheimer’s sufferers, Sulbutiamine has been shown enhance the day-to-day lives of these patients when it was conjugated to a acetylcholinesterase inhibitor.
How Does Sulbutiamine Work?
Sulbutiamine works to energize the body via a glutamatergic action where it is able to stimulate the release of glutamate for action on the CNS. Glutamate is the bodies main excitatory chemical responsible for making us feel more awake, as well as having a pivotal role in learning and memory.
Unlike Thiamine, Sulbutiamine is much more lipophilic meaning that its ability to cross through the blood brain barrier is easier and quicker, allowing for an improved route of Thiamine administration to the brain.
Both acetylcholine and GABA have been found as the breakdown product within the body after Sulbutiamine administration, including a higher density of the reward receptors within the prefrontal cortex of the brain.