As one of the racetams, it is likely that Pramiracetam also acts upon the brains acetylcholine levels, with some studies proving this theory to be correct by monitoring the intake of choline by the brain. Choline is used and converted into acetylcholine which is extremely important to many vital parts of our day-to-day thinking. Sustaining attention, feeling alert and keeping motivated are all key aspects of our working life; acetylcholine is one of the tools used by the brain to maintain our higher cognitive states. It has been shown that high levels of acetylcholine are helpful for the formation of short term memory and the brains learning ability. Furthermore, acetylcholine has a vital role when neuronal plasticity is needed and new connections are created in the brain.While sleeping we gain most of our rest during REM states, and these states are maintained by utilizing the acetylcholine available to us.
Pramiracetam may help us to improve our fluid intelligence which is beginning to be recognized as a more influential marker for a person’s general IQ than other more traditional tests. One study has found that fluid intelligence is a better indicator of a child’s future success in academia. As studies have pointed to Pramiracetam as one of the few supplements to improve fluid intelligence, it is no wonder that many use it as a stable part of their working routine.
Although one of the newer racetams, research has already proven the safety of Pramiracetam is extremely high. In one, 9 week study, Pramiracetam was used on a total of 448 people and found to have no significant side effects.
How does Pramiracetam work?
Research into Pramiracetam much like some of the other racetams has failed to elucidate an exact mechanism, however, it is fair to assume that based on the structure and similarities to the other compounds, Pramiracetam would follow the usual mechanisms. This would be centered on the AMPA receptor and Pramiracetams ability to modulate this receptor and effect cerebral levels of acetylcholine. Further actions on glutamate levels are likely, which would aid in its ability to promote wakefulness and alertness.