One of the primary difficulties with GABA is its bioavailability, this is why other alternatives have been sought to deliver GABA to the brain. Nootropics must effectively cross the blood brain barrier to have an action on neurotransmitters. Picamilon is absorbed rapidly by the body and can easily cross into the brain to have its effect, this is why Picamilon is more beneficial than GABA alone and can be compared to other GABA derivatives such as Phenibut. The anti-anxiety and calming effects of Picamilon are due to GABA acting as an inhibitory molecule, however, Picamilon is also hydrolysed into Niacin which is effective at exciting the brain much like Sulbutiamine. Niacin is able to speed up cognitive processes and induce a state of excitation via the dilation of blood vessels, which causes an influx of Oxygen within the brain.
No observed toxicity has been found with extensive research into Picamilon in the body, however, due to the effects it can have in inhibition, there are some mild side effects which may occur, including, nausea, rashes and dizziness. If any of these are experienced it is advised to discontinue use immediately.