500mg Phenibut Tablets

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Developed in the Soviet Union during the 1960s, Phenibut (AKA Noofen, fenibut or phenybut) is a naturally found derivative of the body’s main inhibitory neurotransmitter GABA (γ-aminobutyric acid). Phenibut has been shown to exert an anti-anxiety, anti-stress, and general calming effect on the body, comparable to that of Valium (diazepam) and Baclofen. Phenibut has been found to possess nootropic action not only by having neuroprotective effects but also by reducing induced amnesia and facilitating a good night sleep.

Phenibut was deemed so successful by the Russian cosmonaut’s medical team that they decided to make it mandate standard equipment in their medical kit. Phenibut replaced other more conventional tranquilizers, as it did not make the cosmonauts drowsy, and effectively lowered the stress levels without adversely affecting their cognitive performance.

Phenibut is an ideal inhibitory nootropic as it can help users of the more stimulating nootropics wind down if any mild insomnia is seen. It is also beneficial as it improves the natural sleep cycle for an improved night’s sleep and ultimately a better cognitive performance the following day.


Key Findings

Shown to alleviate anxiety, fear, tension and depression [2][3]

Proven effective against toxicity caused by alcohol [7]

Shown to possess anti-oxidant properties [5]

Neuroprotective and anti-amnesia actions comparable to Piracetam [4][8]

Shown to protect against diminished cognition after sleep deprivation [1]




Phenibut has been shown extensively to act as an anti-anxiety, stress relieving substance. Further studies have shown an anti-amnesic and protective action. [2][4][8] Generally recognised in Russia for its nootropic properties, Phenibut has found its way into common Russian medical practice due to its superior action to commonly used tranquilizers. For the Russian cosmonauts the main benefit of Phenibut was the lack of cognitive impairment and sedation seen with other medications available.[9] This was extremely important as stress levels were high during the juvenile years of space travel, with an effective medication needed to relieve stress levels without diminishing performance.

Phenibut is used in Russia for a wide variety of applications including relieving tension, anxiety and fear as well as to improve sleep in psychosomatic or neurotic patients. Post-traumatic stress and stuttering have also seen treatments using Phenibut.[2]

Phenibut is has been shown to exhibit anti-amnesic properties when scolopamine-amnesia was induced, and even surpassed the anti-amnesic effect of Piracetam.[4] Phenibut has shown anti-oxidant effects when tested on the spleen.[5] This health benefit has been further extended when research showed that Phenibut effectively prevented brain injury after alcohol consumption and even prevented damage due to induced hypoxia. [7][8]


How does Phenibut work?

As a GABA derivative it has been shown that Phenibut acts as an agonist to the metabotropic GABAB receptor, with agonist action to the ionotropic GABAA receptor at higher doses. This mechanism allows Phenibut to have a relaxing and general inhibitory effect on the brain. [10] Studies have also shown Phenibut to reduce levels of norepinephrine (adrenalin) within the hippocampus, helping reduce unwanted stimulation further.[6] Antidepressant and anti-anxiety effects are likely due to the increase in dopamine metabolite seen after Phenibut ingestion.[6]


Suggested Use: As a dietary supplement take 1 - 3 tablets per day. Depending on body size and tolerance you may increase this to a maximum of 4 tablets. Do not exceed the recommended dosage in a 24 hour period unless advised by a healthcare professional.

Each tablets contains exactly 500mg of Phenibut. Phenibut is recommended in dosages from 250mg to 1500mg up to twice daily, however, we recommend to dose as needed throughout the day, never exceeding 3 tablets per day. Always start with a low dose and build up should you require it. Phenibut is an excellent nootropic for those who struggle to get to sleep if other more stimulating nootropics with a long half-life have been ingested.

IMPORTANT: Please exercise caution when using Phenibut as tolerance can build up quickly with withdrawals symptoms experience if used daily for extended periods of time. DO NOT use Phenibut everyday, we recommend using phenibut only when needed not exceeding 3 - 4 times per week. If you are unsure please consult a healthcare professional.


Caution: Our products are not intended to diagnose, treat, cure or prevent any disease. Consult with a medical practitioner before taking this product, especially if taking prescription medication. Do not use if pregnant or breastfeeding. Long-term use of these products should be supervised and monitored by a health care professional. Discontinue immediately if any adverse effects occur and contact your healthcare practitioner. Any information presented on this packaging is not to be taken as, or in place of medical advice. This is a food supplement and must not be used as a substitute for a varied and balanced diet and healthy lifestyle. Store in a cool, dark place out of direct sunlight. Do not use if the seal is broken or missing. PLEASE KEEP OUT OF THE REACH OF CHILDREN.


Serving size 1 Tablet

This product was manufractured by : Nootropics Ltd.


Unit 262, 266 Banbury Road, Oxford, OX2 7DL, UK

Each Tablet
Amount per
% Daily
Phenibut 500 mg

† Daily value not established, *Percent daily values are based upon a 2000 calorie diet.

Other Ingredients

Microcrystalline Cellulose, Magnesium Stearate, Dicalcium Phosphate


Phenibut - Cited Sources

[1] http://www.ncbi.nlm.nih.gov/pubmed/22891435

[2] http://www.ncbi.nlm.nih.gov/pubmed/11830761

[3] http://www.ncbi.nlm.nih.gov/pubmed/6131709

[4] http://www.ncbi.nlm.nih.gov/pubmed/20396730

[5] http://www.ncbi.nlm.nih.gov/pubmed/22232912

[6] http://www.ncbi.nlm.nih.gov/pubmed/19334514

[7] http://www.ncbi.nlm.nih.gov/pubmed/18260875

[8] http://www.ncbi.nlm.nih.gov/pubmed/6538101

[9] http://books.google.co.uk/books?id=MFppbhSMygIC&pg=PA209&redir_esc=y#v=onepage&q&f=false

[10] http://www.ncbi.nlm.nih.gov/pubmed/2431377

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