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Noopept: A potent neuroprotective agent

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Please note:Noopept is not for human consumption. It is intended for research purposes only. We do not endorse personal consumption of noopept. This article is for entertainment purposes only. Adverse effects and complications of consuming noopept is the responsibility of the user.

What is noopept?

Noopept is a form of nootropic that closely resembles the structure of most racetams. Technically, noopept is not a racetam for it has no 2-oxypyrrolidine skeleton. However, ithas been grouped under this class primarily because it shares similar functions as to most racetams. Today, the US FDA and other countries do not approve noopept use. Some other countries however have patented this drug as a general nootropic.

Noopept is one of the most potent nootropicagent. It has been dubbed as 1000 times more powerful than piracetam. As such, it is able to exert its effects even at lower doses. Moreover, it is easily absorbed and metabolized by the body more than any other nootropics under the racetam family. This means that its beneficial effects are palpable minutes after ingestion. Nonetheless, it also requires users to be very careful on their dosing practices.

Mechanism of action

The mechanism of action of noopept is similar to most racetams. It works through stimulating or facilitating the functions of the NMDA and AMPA receptor sites. Some studies have also discovered that it has an affinity to the neurotransmitter acetylcholine – all of which contributes to the benefits gleaned from noopept use.

Clinical trials on both human and animal models have shown that administration of noopept promotes ananxiolytic response. It exerts this effect through stimulating Ach nicotinic, serotonin as well as dopamine receptor siteswhich leads to mood improvements. Moreover, earlier and recent studies have shown promising results regarding noopept’s role in increasing the nerve-growth factor (NGF) in the brain. Increased NGF in the brain actually helps in repairing damaged neurons which is particularly beneficial amongst Alzheimer’s disease patients.

Uses and benefits of noopept

Noopeptis used as a general nootropic agent in most countries. It is available by prescription for intellectual enhancement. It may be bought online even without a prescription. However, current and prospective users must take precautions in using this nootropic agent.

Common benefits with noopept use includes mild psychostimulatory effect, improved cognitive ability, increased learning capability, boosts mood (anxiolytic and anti-depressive response), promotes advanced logical thinking ability, heightened memory, easy recall, better perception, decreased lability and enhanced reflexes.

Noopept as a neuroprotective agent

Noopepthas been recognized as a potent neuroprotective agent. Numerous trials conducted to identify its effects revealed that it can prevent the development of Alzheimer’s disease amongst individuals suffering from mild cognitive problems. One study provided evidence regarding noopept’s ability to prevent Alzheimer’s disease. In this particular trial, rat models were used to study the effects of long-term and single administration of noopept. Results of this study revealed that acute administration doesn’t increase levels of NGF and BDNF. NGF and BDNF are neurotrophic factors critical for memory retrieval and cognitive functioning. Long-term administration on the other hand leads to increased levels of the aforementioned neurotrophic factors in the brain. Prolonged administration even potentiated the increased of BDNF and NGF instead of causing tolerance to noopept’s effects. This findings suggest that noopept has the ability to protect numerous cognitive functions whilst protect the brain from damages.

A more recent study conducted in Russia supports the aforementioned positive results of noopept on the brain. In this study, noopeptwas administered to rat models for 28 days. Analysis of data gathered revealed that chronic administration of this nootropic agent decreases the activity of the stress-induced kinases (SAPK) located on the hippocampus whilst increase the levels of BDNF genes on both the hippocampus and hypothalamus of the models. Presence of SAPK and BDNF deficiency increases brain cell degeneration. Hence, decreasing SAPK levels and increases in BDNF gene production would prevent neurodegenerative processes. Through noopept supplementation, such pathogenetic mechanisms involved on the development of Alzheimer’s disease are inhibited.

Experimental studies done using noopept have shown its ability to prevent neurotoxicity from excessive amounts of glutamate and calcium as well as its antioxidant and anti-inflammatory properties. It functions through protecting the brain from neuronal damages, neuroprotective properties and treatment for cognitive problems induced by neurodegenerative diseases. Indeed, noopept is a promising drug for the treatment of cognitive problems (e.g.stroke, Alzheimer’s disease, Parkinson’s disease) induced by post-traumatic and cerebrovascular origins.

Precautions, safety and side effects

Generally, noopept is said to be well-tolerated by humans as compared to piracetam. No dangerous drug interactions has been documented to date. Despite this, users must take precautions as it may cause immunosuppression. Common side effects include gastrointestinal problems, nausea, insomnia, headache and fatigue. Other important precautions include:

  • Take noopept on lower or recommended dosages as it is a very potent chemical and overdosing is highly possible.
  • Consult your doctor before taking noopept especially if you are suffering from any medical condition or taking other supplements or medications.

If you are pregnant or lactating seek your doctor’s advice before using noopept.

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