As many studies have suggested, higher levels of the brains most important cognitive neurotransmitter acetylcholine, are linked to improved attention, focus and memory. Nefiracetam has been able to increase the synaptic volumes of acetylcholine. This effect works in conjunction with an action on N-Methyl-D-aspartate which has shown a vital role in the action Nefiracetam can have on LTP or Long Term Potentiation. LTP is one of the most interesting phenomenons within neurology, as it has the potential to increase the firing frequency between some neurons and may even be one of the constituents of neuronal plasticity mechanisms.
Research into Nefiracetam have successfully proven its effectiveness at diminishing the symptoms caused by induced seizures on rodents. It has also been found to act as a barrier to prevent cell death in cases where rats have been subject to an induced brain damage by Glutamate and Veratridine. Further studies have found a link between a reduction in symptoms for those with apathy after the effects of a stroke, and for those with more serious forms of depression.
Scientist have found that Nefiracetam can stimulate a higher rate of blood flow to the brain which is attributed to a general boost in cognitive performance, furthermore, it has been found to potentiate the release of Glutamate which can promote a feeling of being more awake.
How Does Nefiracetam Work?
Nefiracetam is able to exhibit the effects outlined above mainly due to its action as a stimulator of cerebral acetylcholine and glutamate. Much like the other racetams it is thought to act upon the AMPA receptor as a modulator, further facilitating the use of acetylcholine with the brain. These actions allow Nefiracetam to improve the memory, attention and general learning of volunteers and healthy individuals in scientific research. Some studies have shown an ability to activate the CREB phosphorylation pathway for its effect on those suffering from low mood.