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Melanotan I: What is it and its beneficial effects?


Please note: This article is for informational purposes only. Melanotan I is strictly for research purposes only. Any undesirable effects associated with intake of this peptide are sole responsibility of the user.

What is melanotan I?

Melanotan I, named as Afamelonatide by the developers, is a peptide that was originally created at the University of Arizona. It is a synthetic analog of the naturally produced melanocortin peptide hormone known as alpha-melanocyte stimulating hormone or a-MSH. It has been shown to induce deep tanning or skin pigmentation through the process of melanogenesis. Clinical trials have shown that it significantly help decrease the damage to the exposed skin caused by harmful ultraviolet rays.

How does it work?

The mechanism of action of melanotan I have been associated to mimicking the natural tanning process. Primarily, it promotes photoprotective activities through stimulating a signaling cascade through activating the skin’s melanocytes – cells that produces melanin. After which, it triggers a series of responses and actions that leads to the production of eumelanin, the photoprotective type of pigment (black or brown) instead of pheomelamin, the non-protective type of pigment (red or yellow).

The earlier binding activity of melanin leads to the stimulation of cyclic adenosine monophosphate (cAMP) production from adenosine triphosphate (ATP) and the activation of AC or adenylate cyclase. In turn, cAMP stimulates protein kinase A (PKA) leading to the synthesis of microphthalmia-associated transcription factor (MITF) protein.

MITF functions through activating specific genes that includes those involved in melanogenesis. This activity then leads to increased levels of melanogenic enzymes in an individual melanocyte. The levels of this enzyme in a melanocyte indicate the cell’s ability to produce eumelanin rather than pheomelanin. The release of eumelanin instead of pheomelanin is the primary mechanism on how melanotan I help in increasing skin pigmentation to provide photoprotection against UV radiations. This is the major therapeutic benefit that can be gleaned from the administration of melanotan I.

What are the benefits of melanotan I supplementation?

Numerous studies as well as anecdotal evidence have shown that melanotan I is effective in producing the following effects:

Treatment of UV related skin problems

Clinical trials have shown that melanotan I treatment can actually help in relieving the symptoms and severity of erythropoietic protoporphyria (EPP), polymorphous light eruption (PMLE or PLE), phototoxicity, solar urticarial, and skin cancer. These trials discovered that melanotan I is a very promising drug peptide which could potentially benefit numerous patients suffering from these skin conditions. Most of these studies have reached trial completion with significant and substantial positive results. For this reason, it has been approved as a prescription drug for the treatment of EPP in Australia and Italy. Other countries are expected to follow suit once all these successful trials are completed.

Achieving a deep, natural tan

Aside from treating a host of skin problems, melanotan I can help in achieving a deep, natural tan without the hassle of exposing yourself to the harmful rays of the sun for a prolonged period of time. It actually helps in doing so while preventing painful sunburns, ghastly peeling or redness. This is also the primary reason why bodybuilders are very interested in melanotan I use. Having a deep tan actually accentuates the effects of those lean and bulky muscles.

How should you use melanotan I?

Melanotan I is actually purchased as a lyophilized powder which needed to be reconstituted in bacteriostatic water. The concentration of your melanotan solution depends on the amount of reconstituted water you use which is usually between 1 ml to 5 ml. We recommend however that you use 1 ml to 2 ml reconstitution to reduce the volume of substance injected in your body.

It is highly advisable that you change syringe every time you reconstitute and every time you inject yourself with melanotan I. You might also want to wipe the top of your vial with a sterile alcohol swab to prevent contamination and or infection. Ensure that you wipe the site of injection as well with an alcohol swab. Administer melanotan I in subcutaneously (adipose tissue layer).

How much melanotan should you use?

In purchasing and using melanotan I, ensure that you have carefully read the stock at hand to prevent dosage errors. The recommended starting dose is 1 mg. We suggest that you increase this amount by .25 mg per day to evaluate how your body reacts to it. Ensure that you limit your intake from 2 to 3 mg a day.

What are the side effects of melanotan I use?

Side effects associated with melanotan I use include:

  • Nausea
  • Fatigue
  • Dizziness
  •  Vomiting
  • White patches or unequal tanning on the different parts of the body
  • Headaches
  • Itching
  • Suppression of appetite
  • Appearance of new mole or darkening of existing ones
  • Facial flushing

Most of these side effects actually go away on its own after a few days. Nonetheless, you must consider if these side effects are worth buying and using melanotan I.