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IDRA-21: Description, benefits and mechanism of action


Please note: This article is for informational purposes only. We do not encourage intake of NSI-189 any other nootropic substance listed/discussed/sold on this site. Any undesirable side effects from intake of NSI-189 are sole responsibility of the user.

What is IDRA-21?

IDRA-21 is one of the newer nootropic compounds available in the market today. It is considered as an ampakine stimulant that works as a cognitive and memory enhancer and a potent stimulant. It is also known to help in the reversal of cognitive deficit symptoms. Some of the most notable ampakines include aniracetam, sunifiram and unifiram.

This nootropic agent is also categorized as a benzothiadiazine with a chiral molecule. Some animal studies have shown that it is very effective in improving memory and learning capacity. It is 10 to 30 times more potent than aniracetam and is able to decrease neurodegenerative symptoms that are sustained for up to 48 hours after last dosage administration. When used appropriately, it is relatively safe however; you must bear in mind that it actually worsens neuronal damage following ischemia due to seizures or stroke.

Other names of IDRA-21

IDRA-21 is also known for its other names including:

  • 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
  •  C8H9ClN2O2S

How does IDRA-21 works?

IDRA-21 is an ampakine compound. These ampakines modulates AMPA receptors in your brain. The AMPA receptors on the other hand are responsible for increasing the speed of synaptic transmission between neuronal cells whilst improve long term potentiation and synaptic plasticity. IDRA-21 further works through promoting positive modulation or allosteric activation. There is also evidence showing that it supports learning and memory as well as increased synaptic response.

IDRA-21 also binds to certain receptors in the brain that promotes excitatory responses such as increased attention, alertness and responsiveness. It also potentiates the effects of neurotransmitters particularly glutamate. Note that glutamate is one of the two most important neurotransmitters found in the brain responsible for promoting quick reasoning, increased focus, better attention span, and improved deduction.

This nootropic agent is able to exert its effects in glutamate through decreasing glutamate receptor desensitization. Decreasing the desensitization of glutamate receptors is important to prevent problems associated with it such as decreased attention span, reasoning skills, responsiveness and alertness. Through this mechanism, IDRA-21 is able to maintain and sustain numerous cognitive processes associated with glutamate activity.

What are the benefits of IDRA-21 supplementation?

Benefits associated with IDRA-21 supplementation include the following:

  • Increase in cognitive performance
  • Increased alertness and wakefulness
  • Improved short term memory
  • Enhanced task accuracy
  • Neuroprotective properties – protects the brain from age-related cognitive deficits
  • Potential treatment for schizophrenia and depression

Is IDRA-21 safe to use?

When used accordingly, IDRA-21 is safe to use. Note however that it is a very potent ampakine compound and there is little knowledge regarding its toxicity in humans. Hence, when used excessively, it can become a neurotoxic agent that may cause neuronal death in the hippocampal region. Therefore, it should not be used to patients suffering from seizure or have had just a stroke attack as it can exacerbate cognitive decline. It is very important to follow the recommended dosage and precautionary measures to prevent undesirable severe adverse events.

Anecdotal evidence from first time user report that it cause increased anxiety, hypomania, manic episodes, headaches, rapid sweating, insomnia and depression symptoms. These side effects may also manifest itself weeks and months after intake. Some reported that this downhill makes it not worth a try. As such, it is very important that you watch out for these symptoms. We suggest that you take a small amount of IDRA-21 on your very first administration to assess how your body reacts to it. You must also consider not using it continuously. Otherwise, we strongly suggest that you go for other safer and non-risky nootropic compounds.

What is the recommended dosage?

Animal studies have shown that 3 to 5.6 mg/kg taken via the oral route is effective. Individuals who have tried using IDRA-21 suggests daily intake of 5-25 mgs.

Can you stack it with other nootropic agents?

Due to lack of evidence as well as its potential excitotoxicity effects, it is highly recommended that you do not stack it with other ampakine compounds such as aniracetam as well as other compounds that influence glutamate.


IDRA-21 is a new nootropic agent. It appears to produce beneficial effects such as improved memory, learning capacity, increased alertness and wakefulness and quick reasoning. Nonetheless, there is little evidence regarding its safety and efficiency. Some other studies have even shown that it increases cognitive damage risks amongst patient who just suffered from stroke or seizures. Moreover, reports of undesirable side effects are given even after a single dose of IDRA-21. Therefore, we highly suggest that you choose other safer and risk-free nootropic agents that are backed up with clinical trials and research studies.