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Ethylphenidate: Physical and intellectual effects


Please note: As of 10th April 2015 Ethylphenidate is a controlled substance in the UK
We strictly do not endorse the consumption of Ethylphenidate as it is strictly intended for use in non-clinical scientific research. Not for human consumption. As such, this article is strictly for entertainment purposes only. We are not responsible for any side effects due to inappropriate use of Ethylphenidate or any other nootropic agent.

Ethylphenidate is a recently discovered psychostimulant that is very much similar to ADHD medication – a drug that is frequently used to treat attention deficit hyperactivity disorder (ADHD). Not much is known about this compound. Nonetheless, experts in the field agree that methylphenidate and ethylphenidate share some similar characteristics particularly on their mechanisms of action.

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What is ethylphenidate?

Ethylphenidate may be categorized as a psychostimulant having a racemic mixture property. Anecdotal evidence show that it functions as a norepinephrine reuptake inhibitor and a dopamine reuptake inhibitor as well. Despite having similar pharmacological properties to methyphenidate, users report that it significantly causes euphoria as compared to the latter compount. This shows that the subjective effects of these similar chemicals are distinctive from each other.

Furthermore, one study has shown that this metabolite is formed after coingestion of ethanol (alcohol) and methyphenidate – a similar process that results to cocaethylene when both alcohol and cocaine are ingested together. At higher levels of consumption or abuse of both ethanol and methylphenidate, it was revealed that the resulting ethylphenidate in the blood might contribute to drug effects. Still, only a few part of the ingested methylphenidate will be converted to ethylphenidate and would not lead to significant doses.

Today, ethylphenidate remains an internationally uncontrolled substance. Nonetheless, it is banned on certain jurisdictions including Australia, Austria, Denmark, Germany, Jersey, Sweden and USA since it is considered as an analogue of methylphenidate.

Ethylphenidate is now a controlled substance in the UK.


How does ethylphenidate works?

Ethylphenidate has a structural similarity to methylphenidate. As reuptake inhibitors of both norepinephrine and dopamine, it significantly increases the levels of these important neurotransmitters in the brain. It functions through partially blocking or binding with transporter proteins – proteins that eliminates these monoamines from the brain’s synaptic cleft. In so doing, dopamine and norepinephrine are allowed to accumulate in the brain exerting its euphoric effects.

Researches further revealed that ethylphenidate works better as a dopamine transporter exhibiting same efficiency as to that of methylphenidate. Nonetheless, it has lesser activity on the dopamine transporter compared to its parent compound. This dopaminergic activity is primarily accountable for its reinforcing and euphoric effects on humans and study samples (e.g. rodents).


Benefits of ethylphenidate

Benefits of ethylphenidate are mostly subjective accounts from users. These purported benefits are as follows:

Physical effects

Physical benefits of ethylphenidate primarily include stimulation. It increases energy levels of users that have been described as utterly unique – weaker than methamphetamine but stronger than modafinil and caffeine. At meager to moderate doses, ethylphenidate promotes increased productivity. At higher doses, it promotes easy performance of activities such as dancing, cleaning, running, socializing and other types of sports. Some users describe this type of stimulation and reinforcement as “forced.” It also increases wakefulness, alertness and suppresses appetite.

Intellectual effects

The intellectual effects of ethylphenidate intensify with increased dosage intake. Many users describe improved stimulation, potent euphoria, better abstract thinking, and increased focus. At low to moderate doses, these cognitive effects include increased focus, improved sociability, enhanced memory and recall, accelerated thought and motivation enhancement. It also induces a transient feeling of euphoria through inhibiting reuptake of the neurotransmitter, dopamine. It may act as a memory enhances through mimicking the function of its parent compound, methylphenidate.


Ethylphenidate side effects

Ethylphenidate is licensed for research use only and has little history regarding human use. Hence, its long-term and undesirable effects are unknown. Subjective reports from frequents users however reflected that this potent psychostimulant has no identified negative effects on health if used very sparingly. Probable side effects on ethylphenidate abuse include involuntary jerking, general lack of motor control, anxiety, depression, psychosis, dehydration and vasoconstriction. Its side effects may be similar to other ampethamine-like drugs such as increased or irregular heartbeat. Nasal use of this compound may also lead to irritation of mucous membranes.

One study further revealed that unusual high doses of ethylphenidate could cause mortality as in the case of a 32 year old man. This man was a chronic drug user, autopsy however revealed that on all analyzed matrices, high amounts of ethylphenidate was found. This study only shows that abuse of this drug may yield to highly undesirable results.



Never attempt to take ethylphenidate at higher doses as it can lead to involuntary body jerking, jaw clenching, unsteady hands, general body shaking and vibration, lack of motor control and even death.

If you have sensitive mucous membranes, avoid using ethylphenidate that is administered via the nasal route, as it is caustic and abrasive. However, if you prefer to administer this compound nasally, you may perform routine maintenance (e.g., soaking your sinus cavity with water). You can administer ethylphenidate via other routes either orally or intramuscularly.

If you feel jittery after use, it may help that you eat food before and after ingesting ethylphenidate.

It is advisable that you take this chemical sparingly during initial intake to assess your body’s reaction.

Do not attempt to take this drug together with ethanol or any alcoholic substance.

If you are suffering from any medical condition, particularly cardiovascular problem, do not take this drug as it may result to serious consequences.


Recommended ethylphenidate dosage

Because of lack of evidence and scientific research on ethylphenidate, its toxic dosage remains to be unknown. Recreational users are therefore recommended to use this compound sparingly not only to avoid its side effects but also to prevent abuse or dependence. Since it has similar chemical structure to methylphenidate, it was thought to be addicting amongst users.


Where can you buy ethylphenidate?

Despite its illegal status on numerous developed countries, ethylphenidate may be bought in a pre-made or pure form amongst online shops that market chemicals. In many countries, it remains to be legal and a freely available marketable chemical. (As of 10th April 2015 Ethylphenidate is a controlled substance in the UK).