Much like many of the other racetams (Oxiracetam, Pramiracetam, Phenylpiracetam, Sunifiram, and Nefiracetam) we are able to see a similar pattern of benefits, surrounding those of a traditional ampakine. A high safety profile and therapeutic index allows for a very low incidence of side effects among the general public. Some studies have purposely induced chemical brain damage or amnesia to prove the effectiveness of Aniracetam at reducing these states. Aniracetam was shown to protect against brain damage beyond what was previously seen with its predecessor’s.
One of the most used properties of Aniracetam is for those suffering from low mood and anxious feelings. The benefits for these people have been attributed to Aniracetam’s effect on entactogen neurotransmitters and those responsible for reward. AMPA receptor modulators are extremely important to those with Alzheimer’s disease and many other cognitive disorders as they have the ability to reverse many of the underlying causes before the ailment can take hold. Actions on Glutamate and the AMPA receptor pertain to Aniracetam’s ability to improve neuronal plasticity, memory and attention.
How Does Aniracetam Work?
The action on Glutamate is thought to be key to the learning improvements seen in Aniracetam supplementation. Although most attribute the mood lifting and positive effects to anxiety with Aniracetam’s action on the reward neurotransmitters, some research has pointed towards a slightly different dopaminergic pathway, associated with the signaling via nicotinic acetylcholinergic receptor groups.
Generally, most of the nootropic actions found by researchers studying Aniracetam have been explained by its modulation of the AMPA receptor to which it binds allosterically. This means that it is able to attach to this receptor and change the way the receptor is activated. This means that when important neurotransmitters involved in attention and memory attempt to bind to it, they have a different effect. At the same time, the receptor is able to benefit from a reduction in repeated activation and subsequent desensitization, allowing for a repeated action without diminished effects.