Used as a treatment for Bipolar Disorder, Alzheimer’s disease, and liver diseases.
Shown to improve mood, ability to learn and memory.
Healthy pregnancies require sufficient levels of Choline.
Shown to help those suffering from alcoholism.
Alpha-GPC (AKA choline alfoscerate or alpha-glyceryl-phosphorylcholine) is an extremely bio-available source of choline. Studies have found that Alpha-GPC has a therapeutic benefit to those suffering from cognitive difficulties following stroke and Alzheimer’s disease. After easily crossing the blood brain barrier Alpha-GPC has been shown to act as a parasympathomimetic acetylcholine precursor, meaning it is able to effectively boost levels of the neurotransmitter acetylcholine. Higher levels of acetylcholine have been shown to aid in memory, sensory perception and in sustaining attention. Acetylcholine is also an important neuromodulator implicated in arousal, reward and neural plasticity. Many nootropics, especially racetam nootropics, require large amounts of acetylcholine which can be provided by Alpha-GPC.
Take 500mg – 1000mg per day as required. Although choline can be found in foods such as meat, fish and eggs, it is recommended to supplement yourself with extra sources of choline to allow your body to maintain sufficient levels of acetylcholine should your regular diet be inadequate. This is especially true when a racetam regimen is being taken as the brain will see a higher than normal use of acetylcholine due to the mechanism of their action. Even with a healthy diet it is recommended to take a minimum of 500mg choline per day. It has been found that doses as high as 2000mg of choline per day is well tolerated by the body. For those who do not get enough natural choline in their diet, there may be mild headaches associated with racetam use, which can be prevented with Alpha-GPC supplementation.
As Alpha-GPC is a source of choline the majority of the information regarding its action is based upon the actions of choline and ultimately the actions of acetylcholine within the brain.
Acetylcholine is vital for memory and acts as an important neuromodulator. Acetylcholine has been shown as an essential neurotransmitter involved in the enhancement of sensory perception when we wake up, and while sustaining attention.
Due to the fact that many nootropics work by actively using acetycholine, it is extremely important to have an abundance within your system to benefit from other nootropics. This is particularly true for Noopept and the racetam family, which owe much of their nootropic action to the use of acetylcholine.
Choline has been shown to enhance learning and memory in animal studies.
Choline has been used as an effective treatment in Bi-Polar (Manic Depressive) disorder.
Further studies have proven choline to be effective in treating Alzhiemer’s due to its acetylcholine action, and in treating liver disease.
Choline is widely regarded as an important supplement in pregnancy, and subsequent successful delivery without certain complications.
How Does Alpha-GPC Work?
Alpha-GPC is able to cross into the brain quickly and effectively thus being better at delivering a source of choline than just choline alone. Once within the brain choline is converted into the neurotransmitter acetylcholine which is used primarily within the motor region of the somatic nervous system. Acetylcholine is vital for our ability to sustain attention. Due to its action as a neuromodulator studies have found it can enhance neuronal plasticity aiding in our short term memory and general ability to learn. Choline is also a key component of every cell membrane within our body.
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