The Basics of Acetylcholine Neurotransmitter System and Memory
Individuals who are curious about how various cognitive processes take place should know that acetylcholinesterase is a very important enzyme in the human body, especially in the brain, since it participates in the modulation of the acetylcholine neurotransmitter system. However, this enzyme produces effects that are opposing memory and focus improvements, which is why you may want to learn more about how it works and what influence it exerts on the neurotransmitter system in the human brain.
This article is designed to offer you some simple yet useful explanations on the basic biochemical and physiological processes that revolve around acetylcholinesterase and its impact on cognition. Here we provide a solid explanation as to why incorporating a nootropic supplement that functions as a acetylcholinesterase inhibitor into your memory or focus boosting stack would be a beneficial step.
ACETYLCHOLINESTERASE and the Neurotransmitter Acetylcholine
If you are a beginner in your journey through the exciting world of nootropic supplements, then you will quickly understand two essential concepts. The first concept presents the definition of nootropics, also sometimes referred to as “smart drugs”, which are supplements utilized to boost intellectual and cognitive functions. The second concept revolves around the effects of one of the most important neurotransmitters working in your brain: acetylcholine. You cannot ignore its importance if you are serious about educating yourself on how to boost your memory health and cognition. The synthesis of acetylcholine is stimulated through many supplements including alpha GPC, Centrophenoxine, acetyl L-Carnitine and Citicoline, among a few others. It is therefore natural that boosting your brain’s synthesis of acetylcholine can be accomplished by taking a carefully designed stack containing the above mentioned nootropics.
Beside the importance of acetylcholine production within your brain and its improvement through various nootropics, it is also crucial to achieve an adequate stimulation of acetylcholine receptors because, as you will discover soon, it exhibits a positive influence on many processes that regulate cognition and memory fixation in the human brain. These are just some of the reasons why numerous users prefer to incorporate an acetylcholine enhancer into their stack of nootropics consisting of racetams.
Your body is in a permanent state of equilibrium or physiological balance. It is obvious when we are examining the connection between the acetylcholinesterase enzyme and acetylecholine – a major neurotransmitter in your central nervous system. Your cognitive potential is negatively affected when the concentration of the acetylcholinesterase enzyme is too high because it neutralizes the neurotransmitter acetylcholine before it is able to bind to its receptors. Essentially, this enzyme is monitoring the receptors that are sensitive to acetylcholine, and through its effect on acetylcholine, it can block nerve signals from being transmitted further down the pathway. It is thus logical that significantly elevated acetylcholinesterase levels have a negative impact on you cognition and other facets of intellectual activity.
Why is acetylcholinesterase Needed after all?
There is a solid natural reason for anything that happens in the human body, and virtually any process or structure has a logical physiologic or biochemical explanation. It is certainly true that excessive quantities of acetylcholinesterase are harmful for your memory or cognitive functionality. However, this enzyme is vitally necessary for the proper function of your neuromuscular system. Movements generated through the activation of the neuromuscular system are very delicate and precise, which is why adequate and accurately executed muscle movements need both the enzyme acetylcholinesterase and the neurotransmitter acetylcholine to ensure a refined control. Muscular contraction is a result of acetylcholine mediated effects, and it is known as the concentric stage or phase of muscular work. The enzyme acetylcholinesterase comes into play during the eccentric stage, which is when muscle contraction ceases and muscle fibers are allowed to recover for another phase of contraction. Without the acetylcholinesterase intervention, the muscles won’t be able to rest enough for further work and other movements.
The Essential Science Behind Acetylcholinesterase Inhibitors
It is obvious that acetylcholinesterase is totally necessary for muscle recovery and proper relaxation. If muscle fibers would be continuously stimulated through muscle contraction, the muscular integrity and movement precision would be significantly disrupted. This is the mechanism through which some potent poisons work, and have the ability to cause severe paralysis of the muscles because they function as irreversible inhibitors of the acetylcholinesterase enzyme. A similar negative effect is observed in several varieties of chemical weapons through a mechanism that induces sustained convulsions or seizures that are dangerous and even lethal in exposed individuals.
Still, it is essential to note that beneficial nootropic effects have been observed through the application of reversible inhibitors of the acetylcholinesterase enzyme. These substances exhibit several beneficial therapeutic effects without being associated with any severe or potentially lethal adverse effects, unlike irreversible inhibitors. Nootropic supplements containing reversible inhibitors of the acetylcholinesterase enzyme prevent memory loss or diminish the rate of this natural process, and even cause a decrease in the intensity of Alzheimer’s disease symptoms.
The essential benefits for your cognitive health and memory strength associated with reversible inhibitors of acetylcholinesterase intake consist in a considerably diminished rate of acetylcholine neutralization in your body. Consistent with this mechanism, both enhanced memory and a better cognitive capacity are positive effects that have been well documented in nootropic supplement consumers. It is especially obvious in individuals affected by various degrees of long term loss of memory. Excessive concentrations of the enzyme acetylcholinesterase that these individuals may exhibit can be effectively managed through the regular intake of a reversible inhibitor of acetylcholinesterase.
NATURAL Reversible ACETYLCHOLINESTERASE INHIBITORS
There is a large selection of naturally occurring or artificially synthesized reversible inhibitors of the acetylcholinesterase enzyme that produce a higher acetylcholine-mediated nerve signal transmission. Most of them are quite difficult to obtain, while other substances are available and can be used with a prescription from a doctor. It means that a user is unlikely to experience difficulties with obtaining one or more natural reversible inhibitors of the acetylcholinesterase enzyme because they are widely available in numerous countries around the world. It is useful to remember that some natural inhibitors of acetylcholinesterase can be equally potent and powerful as the varieties one can obtain through a prescription. The following two substances discussed in this article are just as potent and biochemically effective as the drugs that are available with a prescription formulated by a doctor.
Galantamine is currently utilized as medication therapy for individuals suffering from Alzheimer’s disease and its associated cognitive deficiencies. Usually, this remedy is prescribed by a physician; however, you can identify vendors who sell galantamine over the counter at an affordable price. This supplement that blocks acetylcholinesterase reversibly is derived from a plant known as Galanthus, and it is sometimes called “snowdrop.” It can be synthesized artificially also. It is curious that there are no official regulations regarding Galantamine currently, but it is regularly prescribed by physicians in the United States.
The most potent reversible inhibitor of the acetylcholine enzyme that occurs naturally is Huperzine A. It is extracted from a special moss species that grows exclusively in China. The biochemical structure of Huperzine A resembles closely Galantamine. Since it is a naturally derived product, it is widely available without a prescription from many vendors. Everyone who experiences cognitive deficiencies or memory impairments caused by excessive quantities of acetylcholinesterase will discover that a combined Huperzine A and Galantamine intake in the form of supplements will facilitate substantial improvements to their memory problems.
Preserving and boosting your mental capacities is definitely achievable through a stack that incorporates a nootropic from the racetam group, choline and a reversible inhibitor of acetylcholinesterase. Evaluating your current nootropic stack will naturally reveal that you can maximize its associated benefits for your cognition by diminishing the influence of acetylcholinesterase on acetylcholine driven nerve transmission, through a decreased rate of acetylcholine neutralization. The concept that ‘less is more’ applies accurately in this case. Even minute amounts of a reversible inhibitor of the acetylcholinesterase enzyme can dramatically diminish the probability of undesirable results. A cautious approach when using cognitive enhancing supplements is required. Overdose or higher than recommended amounts of reversible inhibitors, but also racetam varieties of nootropics, can increase the chance of unwanted effects in your body.