5g tianeptine

1 for £44.99

ve_vita v_vita
Sorry, out of stock, back in stock soon.



Tianeptine is a well-known antidepressant agent that has a unique neurochemical profile. It has drawn much attention during the recent years because this specific substance challenges traditional hypotheses about depression. Today, experts acknowledge that the antidepressant capabilities of tianeptine, alongside its noteworthy clinical tolerance, can be associated to its neurobiological properties. Glutamate involvement in the mode of action of this antidepressant is well attributed to the available preclinical literature that demonstrates the major role glutamate plays in the mechanism of modified neuroplasticity underlying depression symptoms [1].

Tianeptine acts similarly with selective serotonin reuptake inhibitors (SSRIs). In contrast with many tricyclic antidepressant drugs however, it appears that tianeptine is not associated with sleep, psychomotor, bodyweight, cardiovascular and sleep problems. More importantly, it has a low propensity for user abuse. Moreover, tianeptine has a highly favorable pharmacokinetic profile. It helps increase uptake of serotonin in the brain and considerably decrease neuronal dendrite atrophies induced by stress while having limited distribution, quick elimination, high bioavailability, and not subject to unfavorable hepatic metabolism. The fact that tianeptine is not primarily metabolized by the cytochrome P450 hepatic system differentiate it from most antidepressants available in the market today. This particular difference makes it less likely to experience undesirable drug to drug interactions. Several studies further show that extended treatment with this antidepressant agent helps reduce relapses or recurrences of depression [1] [2] [3] [4]. For this reason, tianeptine is indeed a truly versatile antidepressant agent.


Key findings


Improved memory, critical thinking ability and mental clarity [1] [2].

Treats symptoms of depression including anxiety [1] [5].

Promotes well-being [1].

Neuroprotective properties [1].

Promotes brain cytogenesis [1] [3] [5].

Buy Tianeptine | Buy Tianeptine UK | Thirds Party Tested

Please note: This article is for informational purposes only. We do not encourage intake of tianeptine or any other nootropic substance listed/discussed/sold on this site.This product is strictly intended for research purposes only.


Tianeptine is an antidepressant agent sold under brand names Coacil, Stablon and Tatinol. It was developed by a group of scientists from the French Society of Medical Research in 1960s. Experts consider it as one of the most effective treatments for major depressive symptoms ranging from mild to severe. One of the most notable and popular off-label uses of tianeptine includes its nootropic tendencies. Anecdotal evidence has shown that it can help promote mental clarity, optimal thinking ability and well-being. It is now being marketed as a mood brightening agent, anxiolytic drug and a neuroprotective medicine. It is currently approved for these uses in many European countries, particularly in France where it has been created. 


How does Tianeptine work?


Tianeptine works through involving a dynamic interplay between neurotransmitter systems and its ability to reverse impairments in the glutamate transmission triggered by stress, restores normal neuroplasticity in specific limbic regions, and its ability to influence the glutamatergic system. Its effects on the glutamatergic system could explain the cascade of events prompted by this substance representing its ability to treat depression and promote cognitive benefits.


Tianeptine - Cited Sources

[1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902200/pdf/nihms201077.pdf

[2] http://www.ncbi.nlm.nih.gov/pubmed/11463130

[3] http://www.ncbi.nlm.nih.gov/pubmed/7774514

[4] http://www.ncbi.nlm.nih.gov/pubmed/25759404

[5] http://www.ncbi.nlm.nih.gov/pubmed/25982324

You Might Also Like ...