1g Fladrafinil (CRL-40,941)

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CRL-40, 941 is a white crystalline solid substance that has been described as closely related to both adrafinil and modafinil. It was developed by the French pharmaceutical company Lafon Laboratories as a new research chemical. CRL-40, 941 is known for its other names fluorafinil, fladrafinil and its chemical name 2-{[Bis(4-fluorophenyl)methyl]sulfinyl}-N-hydroxyacetamide[1].

Fluorafinil is a halogenic compound and has been identified as adrafinil’s bis(p-fluoro) ring substitute. As a fluorinated derivative, it has been described as more potent than adrafinil.


Key findings

Anecdotal evidence has shown that fluorafinil can produce the following beneficial effects:

Promote wakefulness and alertness twice more than adrafinil

Improve mood

Decrease feelings of fatigue

Improve memory and learning capacity

Has serenic or anti-aggressive effects


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Please note: This description is for informational purposes only. We do not encourage intake of fladrafinil or any other nootropic substance listed/discussed/sold on this site. This product is strictly intended for research purposes only.


CRL-40, 941 is thought to produce similar beneficial effects as adrafinil and modafinil. It can help in promoting alertness and wakefulness without producing anxiety, dependence and tolerance. For this reason, it can be used to help treat narcolepsy or excessive daytime sleepiness as well as obstructive sleep apnea (OSA). 

Fluorafinil is also thought to produce nootropic like effects including mood improvement, learning capacity and memory processes. Similar to its parent compound, it can also help in decreasing feelings of fatigue. What makes it unique against both adrafinil and modafinil however is its serenic effects whereas it has been identified to decrease aggression in animals [2], [3].


How does fladrafinil?


There are no studies identifying how fluorafinil works and how it influence brain activities. Generally, it may work similarly to that of adrafinil influencing the hypothalamic area and increasing glutamate activities in the brain. This is a safe assumption particularly that it produces similar effects. It is clear however that it is well absorbed by the body after oral ingestion. Its fluorination increases its bioavailability making it more potent and easily metabolized and absorbed by the body [1], [2].


Fladrafinil - Cited Sources

[1] http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=4489095&KC=&FT=E&locale=en_EP

[2] http://www.reddit.com/r/Nootropics/comments/27bjz9/fluorafinil_discussion/

[3] http://en.wikipedia.org/wiki/CRL-40,941

[4] http://www.ncbi.nlm.nih.gov/pubmed/9879236

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