100g Phenibut


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Phenibut UK

 

Overview

Developed in the Soviet Union during the 1960s, Phenibut (AKA Noofen, fenibut or phenybut) is a naturally found derivative of the body’s main inhibitory neurotransmitter GABA (γ-aminobutyric acid). Phenibut has been shown to exert an anti-anxiety, anti-stress, and general calming effect on the body, comparable to that of Baclofen. Phenibut has been found to possess nootropic action not only by having neuroprotective effects but also by reducing induced amnesia and facilitating a good night sleep.

Phenibut was deemed so successful by the Russian cosmonaut’s medical team that they decided to make it mandate standard equipment in their medical kit. Phenibut replaced other more conventional tranquilizers, as it did not make the cosmonauts drowsy, and effectively lowered the stress levels without adversely affecting their cognitive performance.

Phenibut is an ideal inhibitory nootropic as it can help users of the more stimulating nootropics wind down if any mild insomnia is seen. It is also beneficial as it improves the natural sleep cycle for an improved night’s sleep and ultimately a better cognitive performance the following day.


Key Findings 

Shown to alleviate anxiety, fear, tension and depression.[2][3]

Proven effective against toxicity caused by alcohol.[7]

Shown to possess anti-oxidant properties.[5]

Neuroprotective and anti-amnesia actions.[4][8]

Shown to protect against diminished cognition after sleep deprivation.[1]


Details 

Phenibut has been shown extensively to act as an anti-anxiety, stress relieving substance. Further studies have shown an anti-amnesic and protective action.[2][4][8] Generally recognised in Russia for its nootropic properties, Phenibut has found its way into common Russian medical practice due to its superior action to commonly used tranquilizers. For the Russian cosmonauts the main benefit of Phenibut was the lack of cognitive impairment and sedation seen with other medications available.[9] This was extremely important as stress levels were high during the juvenile years of space travel, with an effective medication needed to relieve stress levels without diminishing performance.

Phenibut is used in Russia for a wide variety of applications including relieving tension, anxiety and fear as well as to improve sleep in psychosomatic or neurotic patients. Post-traumatic stress and stuttering have also seen treatments using Phenibut.[2]

Phenibut is has been shown to exhibit anti-amnesic properties when scolopamine-amnesia was induced, and even surpassed the anti-amnesic effect of Piracetam.[4] Phenibut has shown anti-oxidant effects when tested on the spleen.[5] This health benefit has been further extended when research showed that Phenibut effectively prevented brain injury after alcohol consumption and even prevented damage due to induced hypoxia.[7][8]  


How does Phenibut work? 

As a GABA derivative it has been shown that Phenibut acts as an agonist to the metabotropic GABA B receptor, with agonist action to the ionotropic GABA A receptor at higher doses. This mechanism allows Phenibut to have a relaxing and general inhibitory effect on the brain.[10] Studies have also shown Phenibut to reduce levels of norepinephrine (adrenalin) within the hippocampus, helping reduce unwanted stimulation further.[6] Antidepressant and anti-anxiety effects are likely due to the increase in reward neurotransmitter metabolites seen after Phenibut ingestion.[6]

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Phenibut - Cited Sources

[1] http://www.ncbi.nlm.nih.gov/pubmed/22891435

[2] http://www.ncbi.nlm.nih.gov/pubmed/11830761

[3] http://www.ncbi.nlm.nih.gov/pubmed/6131709

[4] http://www.ncbi.nlm.nih.gov/pubmed/20396730

[5] http://www.ncbi.nlm.nih.gov/pubmed/22232912

[6] http://www.ncbi.nlm.nih.gov/pubmed/19334514

[7] http://www.ncbi.nlm.nih.gov/pubmed/18260875

[8] http://www.ncbi.nlm.nih.gov/pubmed/6538101

[9] http://books.google.co.uk/books?id=MFppbhSMygIC&pg=PA209&redir_esc=y#v=onepage&q&f=false

[10] http://www.ncbi.nlm.nih.gov/pubmed/2431377

 

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