Tianeptine (Stablon): A nootropic for depression and memory enhancement

20/10/2014 Tags: health
buy tianeptine online

Please note: Researches undertaken to determine the effects of tianeptine are mostly performed using experimental models. Hence, tianeptine is not intended for human consumption. We are not responsible for any side effects or irresponsible use of this nootropic agent.

Tianeptine, more commonly known by its brand name Stablon, was developed by French researchers Michael Spedding and Antoine Deslandes during the 1960s. Since late 1980s, it has been marketed and manufactured as an antidepressant. This antidepressant and potent nootropic is currently being sold in Asia, Europe and Latin America.


Brand names:

Stablon, Tianeurax, Coaxil, Tatinol


What is tianeptine?

Tianeptine is an atypical tricyclic antidepressant drug that is primarily used to treat major depression, social anxiety and oftentimes irritable bowel syndrome (IBS) and asthma. Despite the fact that it is a tricyclic antidepressant (TCA), it has unique pharmacological properties similar to selective serotonin reuptake enhancers (SSRE). Its chemical structure contains three atom rings that enhance re-absorption of serotonin in the brain.

Stablon is known to have nootropic properties that enhances an individual’s cognitive abilities. It has nootropic tendencies enabling increase of thought clarity and improvement of memory, abstract relationships comprehension and learning. It also appears to exert neuroprotective properties to which it prevents pathological changes and glutamate toxicity in the amygdala and hippocampus.


How does tianeptine works

The exact mechanism of tianeptine is yet to be established. Nonetheless, it is thought to cross over the blood-brain-barrier (BBB) directly entering the brain and wielding its effects. Users report that it helps in improving sleep quality, induce relaxation and regulate moods. The following mechanisms explain how tianeptine exerts its effects on humans.



Numerous researches have shown that it exerts its anti-depressant effects through central neuroplasticity and several cellular and neurochemical mechanisms. Stablon acts by reversing stress-induced pathological damage on certain parts of the brain. It protects the brain when an individual or any organism encounters stress. Stressful situations prompt the hypothalamus to produce corticotrophin releasing factor (CRF) or corticotrophin releasing hormone (CRH). This hormone will increase the production of adrenocorticotropic hormone (ACTH) on the anterior pituitary gland which in turn promotes glucocorticoid release. Unrestrained psychosocial and physical stress promotes increased secretion of cortisol from the adrenal glands causing pathological changes on both hippocampus and lateral amygdala. These changes lead to decreased mood and clinical depression.

Stablon reverse and prevents neural damage whilst promotes synaptic plasticity and neuronal health. It also appears that long-term use of this drug normalizes the HPA (hypothalamic-pituitary-adrenal) system. It actually decreases the stress and basal induced activity of the HPA system thus helping tianeptine users to cope on stressful situations. It also helps in decreasing corticosterone, ACTH and CRF thereby decreasing stress and depression.


Other mechanisms

Extended Stablon use decreases apoptosis or programmed cell death in the hippocampus. It also exerts significant effects on the amino acid glutamate – the principal excitatory neurotransmitter of the brain. Through preventing overstimulation of glutamate receptors, entry of Ca2+ is inhibited. Entry Ca2+ into the nerve cells is toxic. It also alters NMDA glutamate receptors resulting to mediation of intracellular and functional effects of stress. Increased sensitivity of glutamate receptors is the primary mechanism of intellect, memory and concentration enhancement amongst its users. This mechanism makes Stablon relatively similar to other nootropic agents such as Sunifiram, Aniracetam and Noopept.

The most recent research on tianeptine on the other hand revealed that it serves as an agonist of delta and mu opioid receptors. Mu opioid agonists promote euphoria which might explain tianeptine’s anxiolytic and mood enhancing properties. This new research prompts extensive research on the mechanisms of action of tianeptine.


Benefits of Stablon


Major depression treatment

Stablon is mainly used to treat mild to severe depression. Its mechanism however differs from tricyclic antidepressants and SSRI to which it was categorized with. Unlike these types of antidepressants that work by preventing serotonin re-absorption, Stablon works by restoring neuroplasticity. Its actions helps in relieving symptoms of depression including suicidal thoughts, concentration problems, insomnia or sleep problems, anxiety, changes in appetite, feelings of worthlessness, anhedonia, fatigue and loss of interest with usual activities.

One meta-analytic study undertaken in 2003 that compared SSRI and tianeptine use in depression treatment revealed positive results. Based on clinical global impression (CGI), tianeptine is as effective in treating depression as SSRIs. As such, Stablon and tianeptine products are acceptable treatments for major depression.


Cognitive enhancement

Studies further show that tianeptin helps in improving learning and memory through preventing programmed cell death and enhancement of behavior against discriminative tasks. It enhances spatial memory and prevents unwanted changes on the hippocampus – the seat of memory and learning. An animal study revealed that tianeptine protects memory thereby promoting long-term recall.

Another study which included 20 patients diagnosed with depression revealed affirmative results. Study participants were treated with tianeptine for three months and underwent cognitive function testing. Results of cognitive tests showed overall improvement in attention, learning processes, immediate memory and reaction time. This study has shown that it enhances not only symptoms of depression but cognitive functions amongst depressed individuals as well.


Tianeptin side effects

In reasonable doses, tianeptine lacks psychotomimetic side effects. Most common side effects reported by users include dry mouth, dizziness, diarrhea, nausea, headache, constipation, fatigue, joint pain, palpitations and hepatitis in rare cases.



Aside from avoiding excessive dosages of tianeptin, precautions must be undertaken if:

  Allergic to tianeptine

  Pregnant or lactating

 Suffering from kidney problems

 • Taking other medications including tetracyclic antidepressants, monoamine oxidase inhibitors (MAOIs) and SSRIs

 • Before using Stablon or any tianeptin products, it is sensible to ask for a doctor’s advice.


Recommended dosage for tianeptin

Generally, recommended dosage for tianeptin is 12.5 mg taken 2 or 3 times a day. Dividing this dosage is important as it exerts its effects on shorter duration. Individuals who plan to take Stablon must start out with a single or half tablet to initially assess its effects. For more accurate dosing instructions, consulting a doctor is important.


Where to buy tianeptin

In most countries, tianeptin (Stablon) is considered as a controlled substance requiring prescription. Online shops (please check here to buy tianeptin online) sell tianeptin as a nootropic agent and is available even without a prescription.