Things you need to know about oxiracetam

12/03/2015 Tags: all

Please note: This article is for informational purposes only. We do not encourage intake of oxiracetam or any nootropic agents. Any undesirable effects from intake of this nootropic substance are sole responsibility of the user.

What is oxiracetam?

Oxiracetam is a nootropic agent more popularly known as an off label cognitive enhancing agent and a mild stimulant. It has been dubbed as five times more active than your typical piracetam in exerting its effects on memory and other cognitive functioning.


Oxiracetam was developed in Italy during the 1970’s. It has been marketed in late 1980’s and has been distributed in European markets thereafter. It has also reached Japan after being licensed by a Japanese pharmaceutical company, to date however, the US Food and Drug Administration has not approved oxiracetam as a drug or supplement.

Unlike its predecessors, oxiracetam is not used by healthcare providers to treat mental disorders. Several animal trials however revealed that it may be effective in improving brain health and preventing cognitive decline. Human studies have also revealed that it may help in treating Alzheimer’s disease, dementia and abuse of organic solvents. These trials have renewed interest towards using oxiracetam in enhancing cognitive functioning for both young and elderly individuals.

What does it looks like?

Oxiracetam is available in various forms such as capsules, tablet and powder. Powdered oxiracetam is whitish in color and has crystalline like formation.

How does it work? 

The mechanism of action of oxiracetam remains to be a mystery. Nonetheless, experts thought that this nootropic substance works through influencing two of the most important neurotransmitters in the brain – acetylcholine and glutamate. Both these neurotransmitters play major roles in thought processing, memory formation, attention, focus and learning. Oxiracetam is thought to help in increasing the levels of these powerful brain chemicals creating more connections between the neurons thereby leading to better cognitive functioning.


Upon ingestion, your gastrointestinal tract will absorb oxiracetam. It is water soluble and immediately exerts its effects in the body, hence, you may be able to feel some of its effects in as fast as 25 minutes. When it reaches the receptor sites of acetylcholine and glutamate, it will bind to them and prevent the breakdown of these neurotransmitters. As a result, the levels of these brain chemicals in the brain increase whilst work more effectively. Through working on both neurotransmitters, oxiracetam is now able to promote improvement on your brain plasticity and communication.

What are the side effects of oxiracetam?

One of the most important things you need to know about oxiracetam are the potential risks of usage. It is a very potent supplement. As such, we recommend that you use it appropriately.

When asked about its safety, we would like you to know that this particular nootropic agent has low toxicity. It is well tolerated by humans and is relatively safe for use. Nonetheless, its effects vary from one person to another. Hence, some may experience some side effects. These side effects include:


Numerous users report headaches after intake of oxiracetam. Headaches occur as similar to other racetams, oxiracetam works through facilitating the levels of acetylcholine and glutamate in the brain. Our brain then needs to have adequate acetylcholine supply to keep up with the higher demand. To prevent this side effect, you must consider taking some form of choline supplement when supplementing with oxiracetam. Most oxiracetam users report elimination of headaches when stacking oxiracetam with choline. Excellent sources of choline include citicoline and alpha GPC.

Upset stomach, nausea and dizziness

Experiencing gastrointestinal symptoms (e.g. upset stomach, diarrhea), nausea and dizziness are most commonly experienced by individuals who are supplementing oxiracetam exceeding its recommended dosage. Note that oxiracetam is a powerful nootropic agent. Hence it is not recommended that you take more than the suggested dose. More importantly, an added dosage has no positive effects to the user; rather, it will cause these aforementioned symptoms. If you experience these symptoms, you must immediately stop taking oxiracetam. These symptoms will be gone in a day or two after stopping oxiracetam intake.

Nervousness, anxiety and insomnia

Nervousness, anxiety and insomnia are some of the less reported side effects of oxiracetam. These side effects are caused by the mild psychostimulatory effects of oxiracetam. Some individuals experience these symptoms because reaction to oxiracetam differs from user to user. These symptoms are mild, and may go away on its own after your body get used to this nootropic substance. You may opt to stack oxiracetam with aniracetam to prevent anxiety and sleep problems.

How much oxiracetam should I take?

Experts recommend that you take 600 to 800 mgs (in 2 to 3 divided doses) of oxiracetam for your daily supplementation. We suggest that you start with low doses on you first week of usage to evaluate your body’s response to oxiracetam.