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PT-141 (Bremelanotide): A potent melanocortin for improving sexual behaviors


Please note: This article is for informational purposes only. We do not encourage intake of PT 141 or any synthetic peptides/nootropics listed on this site. Any undesirable results from intake of PT 141 are sole responsibility of the user.

Other names


Bremelanotide acetate

PT 141

Drug classification

Melanocortin agonists

PT 141 profile overview

PT 141 is a heptapeptide analogue of a-MSH or alpha Melanocyte stimulating hormone. a-MSH is a substance that is naturally produced by the body. Alpha-MSH influences several important body functions such as appetite, lipid metabolism and sexual libido. Bremelanotide is a metabolite of Melanotan II. Studies have shown that Melanotan II induces melanogenesis causing spontaneous erection and sexual arousal in 9 out of 10 male test subjects. This is actually prompted by alpha-MSH through activating specific melanocortin receptors while exerting its effects on the body. Studies show that PT 141 has the ability to increase libido through activating these melanocortin receptors. For this reason, PT 141 has been studied extensively for its ability to treat male sexual dysfunction such as impotence or erectile dysfunction as well as female sexual dysfunction such as sexual arousal disorder. It has been revealed that PT 141 may also help in the treatment of reperfusion injury and hemorrhagic shock.

How does PT 141 works?

PT 141 works through influencing the central nervous system instead of directly affecting your vascular system. As a direct result, it offers increased safety and efficacy over other products such as Cialis, Levitra and Viagra – drugs that belong to the phosphodiesterase-5 (PDE-5) inhibitors.

How is it administered?

PT 141 is administered via the nasal route making it a fast acting, non invasive drug. Prospective users may only need to cleanse the nares as well as the spout of the PT 141 container for hygienic purposes.

Are there any contraindications with PT 141 use?

Although developers state that PT 141 is not contraindicated for patients suffering cardiovascular diseases and who are under nitrate therapy, we highly recommend that it should not be used by individuals suffering from any other medical condition or are taking OTC, herbal and prescribed medications. Doctor’s advice must always be sought out before taking PT 141. It is also not advisable for pregnant and lactating mothers. Despite these precautions, note that PT 141 is a relatively safe and effective medication.

Efficiency of PT 141 for sexual behavior improvement

In the study conducted by PT 141 developers, study results show that it is effective in treating male patient suffering from severe erectile dysfunction and for individuals who are not responsive to standard ED treatment. Its efficacy is also identified to be comparable to patients who are taking PDE-5 inhibitors. It was also revealed that in as much as 50% of erectile dysfunction patients were treated to normal function levels with PT 141 treatment. Furthermore, the research revealed that when used alongside sildenafil, efficacy is greatly increased.

In another study, female patients showed similar positive effects. 18 women suffering from premenopausal syndrome female sexual dysfunction (FSD) were involved in this study. The researchers primarily aimed to evaluate the potential effects of a single dose of intranasal PT 141 on the physiological and subjective sexual arousal and desire measurement amongst these women who are suffering from sexual arousal disorder. Main outcome measures include changes in the vaginal pulse amplitude during erotic and neutral video watching after receiving PT 141 treatment. Study paritciapnts were given PT 141 or placebo. The outcome measure is assessed through vaginal photoplethysmography – a too that monitors vasocongestion. Subjective responses were evaluated using questionnaires.

Analysis of the results revealed that more participants reported moderate or high sexual desire after PT 141 treatment vs placebo. It has been revealed that there is a more positive response regarding genital arousal compared with placebo use. The researchers then conclude that PT 141 may positively influence arousal and desire felt by women who are suffering from female sexual arousal problems. This study further indicates that PT 141 is a very promising treatment requiring more evaluation and studies.


PT 141 is a promising medication for a number of medical conditions. Primarily, it is able to promote lipid metabolism. Moreover, it has cardioprotective properties indicating that it can benefit individuals suffering from heart problems. More importantly, there is enough evidence suggesting that PT 141 may be a very effective treatment for libido and sexual problems amongst males and females. Despite this, prospective users must take extra precautions in using these new treatments.

Buy PT 141

PT 141 is available as an intranasal medication. Users must buy PT 141 in trustworthy sellers and respectable online shops.

- See more at: http://nootropics.net/-PT-141-Bremelanotide-A-potent-melanocortin-for-improving-sexual-behaviors#sthash.LVhv2hz9.dpuf