Nootropic effects of Memantine

28/07/2015 Tags: all

Please note: This article is for informational purposes only. Memantine is strictly for research purposes only. Any undesirable effects associated with intake of this substance are sole responsibility of the user.

Memantine has been around since 1968 upon the initial development and manufacturing of Eli and Lilly Co. Since then, it has been marketed under different brand names such as Ebixa, Memox, Axura and Namenda. It was considered as the first medicine to be approved by the US FDA and European Medicines Agency for the treatment of Alzheimer’s disease. Currently however, it is categorized as a prescription drug. Henceforth, you may experience some difficulties in obtaining this drug.

Memantine in treating Alzheimer’s disease

Numerous clinical trials have shown the efficiency and safety of memantine in treating Alzheimer’s disease (AD). It is well-tolerated by the human body. It also shows great affinity towards moderate to severe AD through two different mechanisms.

Primarily, experts agree that it acts as a NMDA receptor antagonist. It is thought to prevent the binding NMDA receptors and glutamate resulting to decreased glutamate activity. Hyperactive glutamate activity is identified to be the primary cause of AD. This is also the reason why current medications and treatment regimens for AD targets preventing excessive glutamate activity.

Is memantine a nootropic?

One question that you may have difficulty finding the answer is “Is memantine a nootropic?” Corneliu Gieurgia was the person behind the term “nootropics.” He described it as any substance, may it be foods, herbs, chemicals, supplements, that has the ability to temporarily improve brain functioning. Based on this definition, memantine is definitely a nootropic agent for its ability to improve memory amongs AD patients.

 Nootropic effects of memantine

Amongst Alzheimer’s patients, memantine helps in improving brain functioning as well as memory. A review of subjective reports from otherwise healthy individuals revealed that memantine is able to promote the following positive effects:

  • Improves attention and focus
  • Enhances memory
  • Decreases tolerance build-up of other nootropic substances as well as benzodiazepines
  • Helps in re-sensitizing racetams
  • Increase wakefulness and alertness
  • Demonstrates neuroprotective properties
  • Prevents overstimulation of glutamate activity
  • Has calming properties
  • Wards off intrusive thoughts
  • Increases energy
  • Improves mood and vitality
  • Migraine treatment

Memantine is further identified is a unique substance. It has the ability to promote normal functioning of NMDA receptors while preventing excessive influx of calcium which is so unlike most drugs categorized as NMDA receptors. Indeed, it has been shown to protect the brain from excitotoxicity, improve memory and helps prevent tolerance build-up with psychoactive drug use. Several studies have proven that memantine may be effective in improving opiate withdrawal symptoms as well as heroin addiction.

Are there any side effects associated with memantine intake?

Similar to most drugs, memantine may cause side effects. Some of these side effects include increased anxiety, decreased effects of tianeptine, depression, brain fog and lethargy. Please note however that firs time users may experience confusion or brain fog. These effects are identified as normal and will go away on its own. Other side effects include nausea, diarrhea and vomiting. If you experience any of these side effects, immediately stop intake of memantine and call your doctor.

Memantine in a nootropic stack

Memantine helps in blocking glutamate hyperactivity which often results to neuronal dysfunction. You may use it with AMPA agonists to achieve synergistic effects such as greatly reduced drug tolerance and improved cognitive performance.

Where can you buy memantine?

Please always remember that memantine is a prescription drug. It is illegal to purchase it without any prescription from your physician. However, some reputable online stores are selling this drug for its nootropic effects.