Noopept: A Newbies Guide to this Cognitive Enhance

22/05/2014 Tags: all, students

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Noopept is one of the more recently developed and most potent nootropic supplements available today. Being around 1,000 times the strength of Piracetam, it has become popular amongst those seeking to enhance cognitive performance by a noticeable and large degree. It is known to have a wide range of cognitive enhancing benefits to learning, memory, concentration and focus. Not only this, but research has shown it to have extensive neuroprotective properties as well as possible therapeutic uses in the treatment of Alzheimer’s. Before beginning a Noopept regimen, as with any supplement, it is a good idea to first familiarise yourself with how this nootropic works as well as its benefits and potential side effects.


What are the Benefits of Noopept?

Noopept is used by many for its ability to improve the various facets of memory and learning. It is able to enhance both early stage memory consolidation as well as recall speed, meaning information will be more effectively stored, and easier to remember when it is needed. Practically speaking, these effects can differ between users; while some notice subtle improvements like being able to remember small details; others gain the ability to remember information with an almost photographic memory.  

Noopept is also somewhat unique in the fact that it can stimulate the formation of associative connections between left and right brain hemispheres. This serves to enhance communication between brain regions on a global scale, resulting in further improvement of memory performance and learning capacity, as well increased levels of creativity.

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Noopept is also noted for improving the user’s ability to focus and concentrate. Those who feel sluggish and have problems with “brain fog” will find Noopept provides them with more mental energy and allows them to think with a greater degree of clarity. This can be vital to increasing productivity during prolonged bouts of mental exertion. Many users have also reported increased motivation which will no doubt be of use in academic or workplace environments.

Additionally, this supplement is also shown to have a number of neuroprotective properties, protecting the brain from a wide range of different types of damage ranging from hypoxic conditions to the accumulation of harmful toxins. 


How Does Noopept Work?

Noopept like many nootropics is a psychotropic substance that can easily cross the blood brain barrier to reach its target tissues in the brain. This supplement has a good bioavailability and is among the fastest acting nootropics, reaching maximum concentrations after just 15 minutes. Upon reaching the brain, Noopept acts primarily on AMPA and NMDA receptors that correspond to glutamate. By binding to these receptors, Noopept increases their sensitivity to glutamate, and thus enhances overall glutamatergic activity. Glutamate is an important neurotransmitter and increased concentrations have been associated with enhanced synaptic plasticity, memory, learning and other cognitive faculties commonly associated with intelligence.

This supplement may also modulate the level of other major neurotransmitters. It is believed to have an affinity for acetylcholine receptors, another important neurotransmitter implicated in the processes of learning and memory. Additionally Serotonin and Dopamine systems appear to be affected, and both of these substances are linked to mood among other things. This action on dopaminergic and serotonergic systems gives this supplement some modest anxiolytic (anxiety reducing) effects, though it should be noted that this effect is highly subjective and not all users will notice this effect. These anxiolytic properties can be useful in the context of reducing negative emotions which could otherwise impact cognitive performance, for example many people experience anxiety and nervousness before an exam, or when trying to meet work deadlines.

Noopept also appears to increase the amount of glucose and oxygen that is delivered to the brain. Both of these substances are involved in the production of adenosine triphosphate, a universal energy molecule used by all cells in the body. Consequently, all cells require a constant supply of oxygen and glucose, especially those in the brain that are tasked with a high work load. In fact, neurons begin to die after just a matter of minutes without oxygen which can lead to brain damage. Sufficient oxygen and glucose not only ensures the survival of brain cells but also allows neurons to function at an optimal capacity. Increased levels of oxygen, glucose and subsequent neuronal efficiency is thought to be responsible for many of the alertness and thought clarifying effects of Noopept.

As mentioned earlier, Noopept also has a wide range of neuroprotective properties that help to maintain the overall health of the brain. It appears to work both as an anti-inflammatory and anti-oxidant, preventing damage from inflammation and aiding in the removal of harmful free-radicals. It also protects against excitotoxicity, accumulation of toxins and physical trauma. Additionally, studies have shown that this supplement stimulates the release of two endogenous proteins; brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Both of these substances are thought to promote the growth and repair of neurons, thus reducing the risk of developing neurological deficits.


Recommended Dosage

The recommended dosage for those that are new to Noopept is around 10mg two or three times a day. Administrations should be spaced equally throughout the day to ensure a consistent supply of the supplement as Noopept has a relatively short half-life. Common daily dosages for most individuals is between 10 and 30mg, although some may find that up to 40mg is required to achieve the desired level of cognitive enhancement. It is highly advised against using more than 60mg in a day as this may result in excessive stimulation of glutamate receptors. Noopept is usually taken orally with a meal, or sublingually by dissolving it under the tongue. As with any supplement, it is advised that you consult a doctor before using Noopept to avoid drug interactions and ensure this supplement is suitable for you.


Potential Side Effects

Despite the fact that Noopept is among the potent nootropics, it is still deemed to be quite safe with no serious tolerance or withdrawal issues, and a very low level of toxicity. As it is so potent, very little is needed to achieve significant cognitive enhancing effects, so users do not normally experience gastrointestinal distress that is sometimes seen when using large amounts of other nootropics. Additionally some evidence even suggests that Noopept can prevent headaches, which is a common side effect of some other cognitive enhancing supplements. However, there are a few side effects that should be noted, although these only tend to occur when using dosages in excess of the recommended level. This can include headaches, gastrointestinal distress, insomnia, fatigue, and nausea.


Noopept Stacks

Generally speaking, the fact that Noopept is so potent means that for many users, it is adequate as a standalone supplement. Although not recommended for new users it can be combined with other nootropics. For example, Noopept can be stacked with a choline source such as Citicoline to help negate some of the potential side effects. Others find that Noopept works well with racetams which can potentiate its effects, as well as broadening the range of benefits obtained.

There are a huge number of different Noopept based stacks to try once you are comfortable with using the supplement independently. While experimentation is recommended to ensure you get the most from your stack, you should be sure to carefully research each supplement, and experiment with dosages methodically and incrementally to reduce the possibility of negative side effects.