MGF Profile Overview

07/06/2015 Tags: all

Please note: This article is for informational use only. We do not encourage intake of MGF or any other peptides/nootropics listed on this site. Any undesirable effects from use of MGF are sole responsibility of the user.

MGF, short for Mechano Growth Factor is one of the most recent craze in the bodybuilding community. It has been used by bodybuilders, athletes and sportsmen alike due to its purported anabolic effects which promotes increased muscle mass, lean muscles, physical performance and fat loss. This profile overview are the things that you  must know before purchasing or using MGF.

Other names

Mechano Growth Factor



Please do not confuse MGF with PEG MGF. PEG MGF is a pegylated Mechano Growth Factor – wherein your usual MGF has been added with polyethylene glycol. Polyethylene glycol, PEG for short, is a non toxic substance that increases the length of efficiency or half-life of MGF. This means that it increases the length of time that MGF is exerting its effects in your body from minutes to hours. Hence, one can say that PEG MGF is the enhanced version of MGF.

What is Mechano Growth Factor (MGF)?

MGF was first discovered by a group of researchers in the human muscle. It is also known as IGF-1Ec. MGF is a repair factor or growth factor that is derived from a muscle tissue that has been damaged or injured. It is also found on exercised muscle tissues.

Compared to other IGF variants, MGF is very special because of its role in muscle growth and development. Research and anecdotal evidence has shown that it is able to help with the regrowth and improvement of wasted or atrophied tissues through increasing the regulation of protein synthesis and activating the stem cells found in the muscles. Its exceptional ability to help in muscle regrowth can help in lessening speed of recovery whilst increase muscle growth.  

Furthermore, MGF is able to activate stem cells through initiating muscle satellite cell activation alongside its ability to improve its IGF-1 receptor activities. As a direct result, MGF is able to improve turnover of protein synthesis. Hence, if MGF is used efficiently and correctly, it could greatly help in increasing muscle mass over time.

How does MGF works?

Before explaining how synthetic MGF works, you must know that the liver naturally produces two types of MGF splice variants. The first one is IGF-1Ec. IGF-1Ec stimulates your satellite cells to be activated and it is considered to be the closest IGF variant of the synthetic MGF. The second MGF splice variant is IGF-1Ea. Compared to IGF-1Ec, IGF-1Ea is far less anabolic.

Synthetic MGF only works in the body after the introduction of mechanical overload towards your muscles (e.g. after weight training or heavy workouts). When your muscle is subjected to exercise or injury, IGF-1 gene is released which is then spliced as an immediate response of your body. Primarily, the early splicing stimulates the activation of satellite cells allowing the stimulation of undamaged cells to grow new muscle tissues and fibers. The presence of MGF also helps with the upregulation of protein synthesis. After which, systemic release of IGF-1Ea   from your liver occurs – a process that also helps with the upregulation of protein synthesis within your body. Simply put it, the primary anabolic mechanism of MGF is related to the release of IGF-1 splice variants during muscle regrowth and healing.

How to properly use MGF

Training, bodybuilding and extreme physical activities causes muscle breakdown and muscle tissue & cells damage. Note that human muscles are post-mitotic tissues, hence, cell replacement is not a viable option for tissue repair. If your body is unable to repair your damaged muscle cells, they die leading to weaker and smaller muscles. Apparently, MGF is able to stimulate muscle regrowth and development.

Injection of synthetic MGF could help increase the speed of your recovery from muscle injury. It could also increase your muscle cells through stimulating your satellite cells into maturity. To achieve this, you must use MGF in proper dosages and as recommended by manufacturers.

Is it safe to use?

Generally, there have been no reports of extreme side effects associated with MGF use. Nonetheless, prospective users must ensure that they take extreme precautions in using this substance particularly that it is administered via parenteral route. It is also advised that MGF at recommended dosages only. Some authors recommend 200 mcg of MGF used bilaterally.

Although considered generally safe to use, individuals suffering from any medical condition or are taking any prescribed/OTC/herbal medications should consult their physicians first. Lactating and pregnant mothers should also not use MGF.


Despite its anabolic activity, many people prefer PEG MGF than buying MGF. This is so as MGF has very short half-life lasting with 5 to 7 minutes only. Moreover, it should be used immediately after workout or physical activities as it wouldn’t work with an undamaged muscle tissue. Still, it may be an effective treatment for individuals suffering from muscle wasting medical conditions.