Highlight: Fasoracetam and Coluracetam

16/03/2015 Tags: all

Please note: This article is for informational purposes only. We do not encourage intake of fasoracetam coluracetam or any nootropic agents. Any undesirable effects from intake of these nootropic substances are sole responsibility of the user.

Use of cognitive enhancing substances started ages ago from use of caffeine to several herbs – all of which are known to improve both physical and intellectual abilities. Interest on synthetic smart drugs further caught up with the discovery of piracetam. Today, piracetam is backed up with numerous studies proving its ability to improve memory, focus, attention, and learning capacity.

Piracetam is categorized as racetamic nootropic agent. After the inherent success of this nootropic agent, other racetamic substances follow suit. Some of its potent successors include noopept, oxiracetam and pramiracetam. Two of the newest nootropic substances under the racetam family include fasoracetam and coluracetam. This article will cover these new racetam supplements to help you understand how these neurocognitive drugs work, its benefits, and potential side effects.


Chemical name: (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one

What is fasoracetam?

Fasoracetam is one of the newest derivatives of piracetam. Similar to its parent compound, fasoracetam contains the characteristic pyrrolidine structure of all racetamic agents. Despite this similarity, fasoracetam is more potent than piracetam. Its efficiency in improving numerous memory processes naturally caught the attention of nootropic enthusiasts.

How does fasoracetam works?

Fasoracetam works through binding with the GABA receptors in the brain. It specifically works on excitatory GABA receptors thereby stimulating several brain processes. Fasoracetam is also known to stimulate metabotropic glutamate receptors which can increase your intelligence for up to 30% more.

This nootropic drug also works through stimulating your brain’s cyclic adenosine monophosphate – a secondary messenger necessary for many biological reactions. Through this mechanism, it is able to treat several cognitive problems (e.g. Alzheimer’s disease, attention deficit hyperactivity disorder ADHD). It is also able to stimulate the HCN brain channels which enable improved cognitive capacity of elderly patients.

Furthermore, fasoracetam improves choline uptake particularly that it has high affinity for choline. It acts similarly with coluracetam whereas it works as a positive modulator of choline receptors thereby increasing your cognitive functioning.

Conclusively, fasoracetam works through three different mechanisms. First, it works on the excitatory GABA receptors of the brain, stimulate cyclic adenosine monophosphate and increase choline uptake. These mechanisms now enable fasoracetam to improve your cognitive functioning.

What are the benefits of fasoracetam intake?

Some benefits associated with fasoracetam include the following:

  • Enhanced memory
  • Alzheimer’s disease treatment
  • ADHD treatment
  • Increased learning abilities
  • Improved attention
  • Better focus
  • Potent anti-depressant
  • Decreased anxiety
  • Enhanced mental clarity
  • Improved motivation

Anecdotal evidence and some animal studies using fasoracetam revealed that this nootropic agent is very potent in improving memory and learning capacity.

What are the probable side effects of fasoracetam intake?

Fasoracetam is relatively safe for use; nonetheless, it is not yet approved for human consumption. Hence, precautions must be taken to evaluate its effects on your body. Some side effects may include headaches, dizziness, nausea and gastrointestinal distress.


Code name: BCI-540

What is coluracetam?

Similar to fasoracetam, coluracetam is a racetamic agent that contains a pyrrolidine nucleus on its chemical structure. It was initially developed by a Japanese pharmaceutical company as a treatment for Alzheimer’s disease. Its patent was obtained by BrainCells.Inc thereafter. The drug company funded a study to evaluate coluracetam’s efficiency in treating major depressive disorder (MDD). Results of this particular study revealed that it may be effective in treating MDD.

How does coluracetam works?

Coluracetam has similar mechanism of actions with fasoracetam. It is able to exert its effects on the human mind through acting as a choline uptake enhancer. It increases choline levels in the brain whilst stimulate the activities of this essential protein. Through this mechanism, it is able to increase the levels of acetylcholine in the brain. Acetylcholine is a powerful brain chemical thought to play a critical role in learning capacity, memory formation and other cognitive processes.

This particular nootropic substance is also though to potentiate the activities of AMPA receptors in the brain. Through this mechanism, glutamatergic activities are increased leading to improved synaptic plasticity. Note that synaptic plasticity is central to the development of new connections in the brain crucial for the creation of new memories.

What are the benefits of coluracetam?

Some benefits associated with coluracetam supplementation include:

  • Improved memory formation and retention
  • Enhanced conversion of short term to long term memory
  • Better concentration
  • Mood enhancer
  • Potent memory booster
  • Energy booster

User reports associate coluracetam supplementation with sound and color enhancement.

What are the probable side effects of coluracetam use?

Coluracetam is safe for human use; however, it is not yet approved for human consumption. Hence, it is crucial that you first evaluate its effects on your body before continuous supplementation. Since it is a potent nootroopic substance, you might experience some side effects. Some of its mild side effects include headaches and dizziness.


Fasoracetam and coluracetam are newly discovered nootropic agents under the racetam family. Both substances are potent in improving memory, learning capacity, attention, mood, and focus. However, these nootropic agents are relatively new in the market, hence; we highly suggest that you take extra precautionary measures before intake of these neuro-enhancing drugs