Emoxypine: Benefits, Side Effects and Dosage

23/03/2015 Tags: all


Note: This article is intended for informational purposes only. We do not encourage intake of Emoxypine or any nootropic agents. Any undesirable effects from intake of this nootropic substance are sole responsibility of the user.

Emoxypine (2-Ethyl-6-methyl-3-hydroxypyridine) is also known under different brand names including: Mexidol, Mexicor, Mexiprim, Mexifin and Metaprot. It is produced by Russian company Pharmasoft Pharmaceuticals primarily as an antioxidant although it is not approved for any medical purposes in both Europe and U.S. In Russia where Emoxypine was first developed and manufactured, emoxypine serves different application in the medical field.

It is notable that Emoxypine has a biochemical structure that resembles Pyridoxine, a form of Vitamin B6. With this semblance, some benefits of Pyridoxine are sometimes attributed to Emoxypine. Such benefits include function for the central nervous system and brain, as well as its positive influence to red and white blood cells formation.


The benefits that Emoxypine provides aid general health, in particular:

  • Emoxypine act as a Nootropic, whereas it is able to aid concentration and enhance cognition. Emoxypine do not act like other types of nootropics which influence or alter the behavior of various neurotransmitters in the brain like serotonin and norepinephrine. Instead, it works by protecting neurons from low oxygen and low glucose by regulating oxygen level in the brain whilst increase blood flow to the brain. Furthermore, it increases dopamine level in the brain which could help improve cognitive ability.
  • Emoxypine provides neuroprotective effects. Relative to its Nootropic behavior, emoxypine further helps increase focus and enhance learning and memory by protecting neurons from harmful free radicals which could cause damage to the brain’s neurons.
  • Another benefit of emoxypine is its anxiolytic effects. In studies conducted before, it was noted that emoxypine helps reduce feelings of anxiety. Moreover, there were no side effects (such as sedation) which are commonly associated with anxiolytic medications.
  • This drug is known to have anti-stress effects. It is being used by patients during their period of post-stress to help normalize and improve their behaviors.
  • Emoxypine is also known for its antioxidant properties. Accordingly, emoxypine’s main means of activity is its membrane-protective and antioxidant results. It enhances the activity of various antioxidant enzymes, particularly superoxide dismutase while it also inhibits the activity of free radicals which may cause damage to one’s health.
  • Emoxypine also displays anti-inflammatory properties. It can reduce severity of pain and it can further influence rapid recovery of the functions of peripheral nerves and even the spinal roots. In a study conducted in the past, emoxypine’s anti-inflammatory effects have been shown to significantly decrease the back pain involved in Lumbosacral Radiculopathy.
  • Emoxypine exhibits anti-addictive influence in alcohol. It decreases alcohol intoxication and can help prevent and even reverse the damages caused by constant frequent alcohol drinking. It also provides relief against the symptoms of alcohol withdrawal.
  • It also exhibits direct coronarolytic effect whereas emoxypine can increase coronary blood flow which is beneficial for patients with coronary heart disease. It displays hypolipidemic action as it stabilizes lipid synthesis by decreasing LDL or bad cholesterol while increasing HDL or good cholesterol. It further improves condition of patients with coronary heart disease by normalizing oxidative stress.
  • This drug displays cardioprotective effects. It is known to inhibit the effects of ischemia, a condition which causes severe damage to brain and heart tissues. It exhibits anti-ischemic effects by normalizing metabolic processes in the ischemic myocardium whilst improving coronary blood flow and myocardial contraction.
  • Emoxypine can also enhance visual acuity by enhancing the function of the optic nerve and retina.
  • It is also observed that this drug inhibits platelet aggregation.
  • Emoxypine is also known because of its anti-hypoxia, anti-atherosclerosis and anticonvulsant mechanisms of action.

Side Effects

Emoxypine exhibited limited side effects which include:

  • Nausea
  • Dry mouth
  • Dyspepsia
  • Digestive system problems
  • Allergic reactions (e.g. rashes, sores, thrush)
  • Drowsiness


  • Recommended dosage is to take 125-250 mg thrice (3x) daily. The maximum dose daily should not exceed 800 mg.
  • For a therapeutic effect, take 1 to 2 pills of 125-250 mg of this drug daily. Gradually increase dosage.
  • The use of Emoxypine should be stopped gradually.
  • Usage for those under alcoholism withdrawal should be around 1week only.
  • Patients with coronary heart disease should use product at least within 1.5 to 2 months.

Drug Interactions:

  • It is observed that Emoxypine can reduce the toxic effects of ethanol (alcohol).
  • Emoxypine enhances activity by some drugs (i.e. anticonvulsants, anxiolytic, medications for Parkisnon’s disease)


  • Since there’s still insufficient knowledge and studies conducted about this drug, it is recommended that pregnant women, breastfeeding moms and those who are planning to get pregnant should avoid using this product without consulting a physician first.
  • Contraindicated against people with liver problems, renal dysfunction and hypersensitivity to emoxypine or any of its ingredient.
  • In a few cases, patients with asthma or sensitivity to sulfites may develop allergic reactions.