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Coluracetam: A close look to this new cognitive enhancing drug

Please note: This article is for informational purposes only. We do not endorse intake of coluracetam or any nootropic agent. Any undesirable effects from intake of coluracetam are sole responsibility of the user.

Coluracetam is currently gaining attention from nootropic enthusiasts nowadays. Despite being recently developed, it is aggressively penetrating the neuroenhancing drug market due to its purported potent beneficial effects on the human brain. In light of this, this article will provide a closer look on this newly developed cognitive enhancing drug.

Other names



N-(2,3-dimethyl-5,6,7,8- tetrahydrofuro[2,3-b] quinolin-4-yl)-2- (2-oxopyrrolidin-1-yl)acetamide


Coluracetam was primarily developed in Japan. In 2005, the pharmaceutical company Mitsubishi Tanabe Pharmaceutical Company first obtained coluracetam’s patent. This patent was handed down to BrainCells Inc. later on. BrainCells Inc. is a drug manufacturing company that manufactures and creates pharmaceutical products geared to treat cognitive disorders. After gaining coluracetam’s patent, BrainCells Inc. conducted studies to evaluate its effects in Major Depressive Disorder (MDD). Results of this study revealed that coluracetam may be effective in treating MDD co-morbid Generalized Anxiety Disorder (GAD). To date, coluracetam continues to be studied although no country has identified it other than as a research chemical.

What is coluracetam?

Coluracetam is a cognitive enhancing drug under the racetam family. Structurally, it has a modified pyrrolidine structure similar to its predecessors. It is primarily a cholinergic type of nootropic agent powerfully acting as a choline uptake enhancer. It helps in increasing the levels of choline in the brain and body.

How does coluracetam works?

Coluracetam has some definitive mechanisms of action. First, it is identified as a high affinity choline uptake (HACU). HACU is the uptake of choline (one of your body’s most essential nutrient) at the synaptic level aimed to promote synthesis of acetylcholine. As a HACU, coluracetam acts as a rate limiter allowing your brain to convert choline to acetylcholine easily. Through increasing the levels of your acetylcholine, your alertness, memory and focus are improved.

This nootropic agent is thought to help in potentiating your brain’s AMPA receptors. It does so through helping with AMPA potentiation resulting to better memory capacity and learning abilities. Coluracetam is further identified to help with glutaminergic neurotransmission. Some studies have shown that it was able to decrease the excitotoxicity caused by either calcium or glutamate influx further helping in repairing and giving a boost to several cognitive activities.

How should you use coluracetam?

Since coluracetam is a fairly new nootropic substance, there are limited studies regarding its effective dosage. Some studies however show that 240 mgs a day taken in divided doses is safe for human use. If you are unused or just starting out with coluracetam, we highly recommend that you take it one step at a time. Starting with a dose of 20 mgs will already provide beneficial effects. You can increase this dosage as you get used to it for optimal results.

What are the benefits of coluracetam?

A host of benefits have been associated with coluracetam supplementation. Some of these beneficial effects include:

  • Memory improvement (particularly amongst individuals with impaired memory processes)
  • Treatment for MDD with GAD patients
  • Anxiolytic
  • Treatment for depression
  • Improved decision making skills
  • Increased alertness
  • Enhanced focus
  • Better learning skills

User accounts also show that coluracetam helps in increasing motivation, cognition and moods particularly if stacked with other racetamic agents. Some nootropic enthusiasts deemed it helpful in improving vision acuity.

How long does coluracetam takes effect?

Coluracetam is a fast acting nootropic substance. 30 minutes after ingestion, you may already feel its positive effects on your body. Expect that its effect will decrease after 3 hours of oral intake. We therefore suggest that you divide your dosing accordingly.

Is coluracetam safe to use?

Studies done to assess coluracetam’s effectiveness reveal that oral intake of this nootropic agent for up to 240 mgs daily divided in 3 doses do not cause any untoward side effects. Hence, we suggest that you follow this dosing instruction. Headache, nausea and upset stomach may occur that is why it is critical that you assess your body’s response to this drug. To prevent headaches, some suggest that you take it with excellent choline sources such as Centrophenoxine and CDP Choline. You may skip this suggestion if you want as coluracetam is an excellent source of acetylcholine itself.

Coluracetam is an excellent nootropic agent that is able to exert its beneficial effects in the human body safely, immediately and efficiently. For these reasons, it is one of the most potent nootropic substances under the racetam family. Nonetheless, further studies are needed to unearth its positive effects on the body whilst identify how it should be taken for optimal results. Prospective users should always undertake precautionary measures before taking coluracetam.