Centrophenoxine: How does it improve your memory?

04/03/2015 Tags: all

Please note: This article is for informational purposes only. We do not encourage intake of centrophenoxine or any nootropic agents. Any undesirable effects from intake of this nootropic substance are sole responsibility of the user.

Nootropic agents are supplements known to improve memory, boost brain health and even help in improving some of your physical functioning. You may be wondering how these substances are able to exert its effects in your body and mind. Well, most work its magic immediately and efficiently upon intake and you may be wondering how these substances are able to exert its effects in your body and mind. Firstly, let me reassure you that there is a whole lot of science behind these agents’ effects on the body. And since there are numerous types of nootropic agents, not to mention its derivatives and such, we will start with centrophenoxine.

Centrophenoxine is one of the nootropic agents that are often overlooked by many noot beginners due to lack of knowledge regarding this substance. For this reason, we decided to provide you a more in depth explanation on how this particular nootropic agent works.

What is centrophenoxine?

Despite being the lesser understood nootropic supplement, centrophenoxine, also known as meclofenoxate, has been studies by neurology experts for more than 50 years. From these studies, researchers discovered that it is both a cholinergic and a neuroprotectant compound. It is an altered version of dimethylethanolamine or DMAE developed to easily cross the blood brain barrier (BBB). Since it is the improved version of DMAE, it exerts similar effects to which it is able to improve alertness, attention, focus, memory and learning capacity. It also acts as a neuroprotectant protecting the brain from chemicals and toxins that can damage the brain. Numerous studies have revealed that it is a very potent agent to combat age related brain deterioration.

How does it work?

How do centrophenoxine really works? To answer this question, we have created a simplified explanation for you.

Centrophenoxine as an excellent source of choline

Choline is a B vitamin that has long been identified as an essential nutrient needed by the human body for normal functioning. You can get from dietary resources including red meat, liver, eggs and some dietary supplements (e.g. choline bitartrate, choline chloride). Although choline is readily available from many resources, choline supply from these resources has poor bioavailability – this means that it may not be able to reach your brain as 60% of the choline is broken down on your intestines. Choline from centrophenoxine is of higher quality as it contains DMAE which cannot be digested by intestinal bacteria. Moreover, it is better absorbed by the blood increasing the probability that it will be able to reach the brain easier and faster.


Centrophenoxine increases choline levels in your brain

Two things may happen once the choline from centrophenoxine reaches your brain. First, it may be converted into phosphatidylcholine - once it becomes phosphatidylcholine, it will be integrated to your neurons. Choline may also turn into acetylcholine. Acetylcholine is an essential brain chemical that helps in facilitating functions that are related to reasoning, attention and memory. It is involved in numerous memory processes including memory retrieval, formation and conversion of short term to long term memory.

Increased levels of acetylcholine are also related with enhance learning, brain plasticity and data retention. Low levels of this essential neurotransmitter on the other hand have been associated with Alzheimer’s disease, memory loss, cognitive deterioration and age related senility. Centrophenoxine is able to deliver all these beneficial effects of acetylcholine by being an excellent precursor of the said neurotransmitter. It also ensures that there are sufficient levels of choline for acetylcholine production. Centrophenoxine can therefore help in improving intelligence and cognitive functioning amongst its users.

Centrophenoxine improves elimination of lipofuscin in the brain

Lipofuscin is a waste produced by the body as we age. This biochemical waste accumulates on the cells of your brain, skin, heart and lungs. It is noticeable on the skin wherein you see “liver spots” or brown spots on the skin of the elderlies. While liposfuscin accumulation is a normal process that our body undergoes, excessive accumulation may render your cells less functional and may even cause cell death. Accumulation of lipofuscin in the brain will then lead to neuronal death, impaired memory and reduced learning capacity as well.

Centrophenoxin works through decreasing lipofuscin accumulation in the brain cells. Some studies even suggest that meclofenoxate is able to significantly reduce lipofuscin in the brain in as much as 42% within 8 weeks. This enables restoration of memory capacity and slow down aging process amongst the elderlies.

Centrophenoxine improves RNA production

Meclofenoxate has been associated with improving production of RNA as well. This nootropic agent increases RNA production which in turn helps with the release of essential proteins necessary for normal brain functioning. RNA also enables necessary proteins critical for cell repair and memory improvement.

Other than these mechanisms, centrophenoxine is also able to enhance uptake of glucose and oxygen in the brain leading to better memory and cognitive functions.