Beneficial effects of sulbutiamine

31/01/2015 Tags: all

Please note: We do not endorse sulbutiamine or any nootropic drug use. Adverse effects and complications of this drug are sole responsibility of the user.


Sulbutiamine was discovered by Japanese researchers in search for a way to improve the absorption rate of thiamine. Thiamine is an essential vitamin needed to prevent vitamin deficiency and beriberi. Thiamine has the ability to improve your brain functioning. Nonetheless, it does not easily cross the blood brain barrier, which decreases its positive effects on your intelligence. Absorption is further decreased with folic deficiency. These difficulties are actually solved by sulbutiamine molecules making this essential nutrient easily absorbed by your brain. Being able to enter the blood brain barrier is a critical feature of cognitive enhancing drugs to receive its beneficial effects.

How does sulbutiamine works?

After oral ingestion of sulbutiamine, your intestines will absorb it. It will then circulate on your blood going to your brain tissues. After it penetrates your blood brain barrier, it will be broken down into different esters such as vitamin B1. Studies have shown that sulbutiamine will increase the levels of thiamine and its phosphate esters to your brain compared to taking a dose of thiamine itself. For this reason, sulbutiamine was dubbed as the enhanced or improved precursor of thiamine.

Sulbutiamine works through influencing the activity of your neurotransmitter dopamine. Dopamine has numerous factors acting towards your learning system, focus and executive function and pleasure sensation. It also helps in increasing the density of dopamine receptors on your brain’s prefrontal cortex. As a direct result, it helps in treating symptoms of asthenia, depression and even curbs behavior inhibitions (e.g. shyness).

What are the benefits of sulbutiamine?

Sulbutiamine is a very popular over the counter nootropic drug. It boasts a host of benefits that makes it an attractive option amongst users. Some studies have shown that it is able to improve memory functioning due to its glutamate and acetylcholine activity. Its ability to stimulate dopamine functioning further helps in aiding cognition improvement. Some benefits associated with sulbutiamine supplementation include:

Mood improvement

Sulbutiamine has been considered as a powerful anti-depressant. It has been shown to decrease inhibition including guardedness, avoidance, and fearfulness on individuals suffering from depression or shyness. This effect is prompted by the influence of sulbutiamine on dopamine and its receptors. Some studies and reports of users have shown that it is effective in regulating moods. However, its anti-depressant effects are normally seen for a short period of time. These effects commonly declines after repetitive use, hence despite its efficiency, healthcare providers do not recommend sulbutiamine as a primary treatment for depression and other mood disorders.

Memory improvement

Some studies have shown that sulbutiamine has the ability to improve memory through potentiating glutamatergic, dopaminergic and cholinergic transmission. It has been shown to improve memory of individuals suffering from schizophrenia. It can also improve the activities of daily living of individuals with mild to moderate Alzheimer’s disease when used with acetylcholinesterase inhibitors. Anecdotal evidence shows that it can improve memory, decision-making capability, planning skills and overall intelligence of users. Reports also show that it can improve alertness, reflexes, attention and energy levels amongst others.

Asthenia treatment

Aside from treating thiamine deficiency, sulbutiamine is an indicated treatment for asthenia. Some clinical trials have shown that sulbutiamine is an effective treatment of asthenia. Other studies however have shown that its clinical efficacy for treating fatigue is inadequate. As such, additional research is needed to evaluate its usefulness in treating this particular medical condition.

Erectile dysfunction treatment

Another possible use of sulbutiamine is as an erectile dysfunction treatment. Its ability to treat some types of erectile dysfunction is still being studied. Many users have reported that this particular nootropic drug has aphrodisiac effects making it easier for men to achieve erection. A study involving 20 patients suffering from psychogenic erectile dysfunction shows that after 30 days of sulbutiamine supplementation, 16 patients were treated.

Off-label uses of sulbutiamine

Aside from its ability to improve mood, memory and energy levels, sulbutiamine is also known for its off-label uses. It is said to promote feelings of pleasure and euphoria amongst users. It has also been used to relieve anxiety, stress and depression. Bodybuilders and dieters also use sulbutiamine as a fat burner and an appetite suppressant.

Side effects

Generally, sulbutiamine is well tolerated by humans, with continuous use and repetitive usage however, you may build tolerance quickly. Hence, it is recommended that you take time off using this particular drug every now and then. Also, you must be mindful of some things. Some of the most common side effects related to sulbutiamine use include irritability and anxiety. These side effects however are likely to occur if you take doses of sulbutiamine higher than what was recommended. Some common side effects of sulbutiamine include:

  • Irritability
  • Anxiety
  • Headache
  • Depression
  • Skin rash
  • Nausea

If you experience these side effects, it is highly recommended that you discontinue sulbutiamine use.