All about aniracetam

04/02/2015 Tags: all

Please note: This article is for entertainment purposes only. We do not endorse intake of aniracetam or any other nootropics. Any untoward effects from ingestion of aniracetam or any nootropic agents discussed in this site are sole responsibility of the user.


What is aniracetam?

Aniracetam is an ampakine nootropic agent classified under the racetam class. It  is purported to be more potent than its predecessor, piracetam. Similar to its kind, this particular nootropic agent is known for its ability to improve and increase numerous cognitive processes. Aniracetam also has anxiolytic properties and act as a memory, attention and focus enhancer. Numerous studies have shown that aniracetam is well tolerated and safe when taken by humans. Nonetheless, it is critical that you know more about this nootropic drug.


Also known as:

1(4-methoxybenzoyl)-2-pyrrolidinone, Ro 13-5057, 1-p-anisoyl-2-pyrrilidinone, CAS 72432-10-1


How does aniracetam works?

To date, the exact mechanism of action of aniracetam remains to be incompletely understood. However, there are numerous theories about how it actually works. Aniracetam is known to cross the blood brain barrier (BBB) easily influencing several important neurotransmitters.


Aniracetam is hypothesized to work through binding with acetylcholine receptors prompting this particular chemical to remain longer in the brain. Through this mechanism, focus, learning and memory is enhanced. Acetylcholine is a powerful neurotransmitter responsible for numerous cognitive processes.


Several experts also assume that aniracetam modulates additional brain chemicals, specifically dopamine and serotonin. Serotonin is a potent neurotransmitter responsible for sleep and wake cycles while dopamine is responsible for movement and mood. Through stimulating these specific chemical receptor sites, aniracetam is able to help in improving mood problems and anxiety.


How should you take aniracetam?

Aniracetam has low bioavailability, hence, it is recommended that you take it at a larger dose to receive its potential benefits. Animal studies have shown that 10 mg/kg to 100mg/kg body weight are efficient in producing its effects. Limited studies on humans also shows that 1000 to 1500 mgs. a day taken in divided doses (twice to thrice a day to be taken after meals) is also effective. Taking aniracetam in divided doses is important as it has a relatively short life.


Aniracetam has a bitter taste, so you might want to take encapsulated aniracetam powder if you prefer.


What are the benefits of aniracetam?

Aniracetam is known to have various effects on the human body. These benefits include:


Improvement on depression and anxiety symptoms

Animal studies have shown that intake of 100 mg/kg body weight aniracetam is effective in decreasing the symptoms of depression in aged animals. However, it is somewhat ineffective in treating younger ones. Research shows that it is able to decrease symptoms of expression through exerting its effects on the dopaminergic receptors.


Aniracetam has been shown to reduce anxiety amongst rats. Anecdotal evidence shows that this effect is replicated in humans as well. Theorists hypothesize that this effect is due to its cholinergic, serotonergic and dopaminergic interactions. Improvements in anxiety symptoms are seen with doses of 10 to 100 mg/kg of aniracetam supplementation.


Neuroprotective properties

Aniracetam seems to have the ability to decrease damage from learning and memory problems caused by traumas and agents such as cerebral ischemia, electro convulsive shock and cholinergic antagonists. It also has the ability to protect the brain from damage incidences by scopalamine to a greater degree than piracetam.


Memory and learning improvement

Researches have shown that aniracetam has the ability to decrease the receptor desensitization rate amongst animal hippocampal area (particularly the quisqualate receptors). This suggests that it might be helpful in promoting memory formation. It also encourages release of acetylcholine.

Moreover, aniracetam also increases the production of serotonin and dopamine through cholinergic transmissions in the prefrontal cortex. Increasing the release of the aforementioned brain chemicals actually promote improvement on one's judgement. This ability may also explain its anti-depression properties. Furthermore, aniracetam is shown to decrease impulsiveness on lab animals.


Alzheimer's disease and FAS treatment

Aniracetam has been shown to affect disease states including fetal alcohol syndrome (FAS), Alzheimer's disease and other cognitive problems. This nootropic agent is able to alleviate symptoms or biologically reverse the changes caused by the aforementioned disorders.


What are the side effects of aniracetam?

Although aniracetam has low toxicity levels, you might still experience some side effects. However, you should not worry about it as symptoms are normally mild. The most common side effect of aniracetam includes headache. Taking aniracetam together with choline sources (e.g. Alpha GPC) will prevent headaches. Other potential side effects include anxiety, nausea, vomiting and other types of gastrointestinal distress. These side effects are generally caused by high dosages of aniracetam. Hence, you might want to decrease your aniracetam supplementation to recommended dosages.