A peek on the science of HMG

12/05/2015 Tags: all

Please note: This article is for informational purposes only. We do not encourage intake of HMG unless otherwise advised by your primary care provider. Any undesirable side effects associated with the use of this hormone are sole responsibility of the user.

Human menopausal gonadotropin, more commonly known as HMG, is a medication usually prescribed by primary healthcare providers as a treatment for fertility disturbances. Currently however, numerous athletes and bodybuilders have been purchasing this medication for an off-label use – that is increasing the testosterone levels to improve one’s muscle mass and physical performance. In this blog article, we will be taking a peek on the science of HMG and how it works in the human body. Doing so is important to provide you an overview about the most important information about this hormone before you go buy your very own HMG stock.

Other names



Human menopausal gonadotropin


How do hormones work in the human body?

It is important to learn how HMG works in the human body. However, before you understand the role it plays during hormonal recovery after androgenic anabolic steroids (AAS) intake, you must learn about the processes that occur in male hormones physiological shutdown.

Upon administering hormones such as AAS into your body, different organs and cells sense this activity. Your body is able to comprehend that there is an invariable testosterone increase in your body. As a direct result, it would be able to sense that your testosterone levels (or other similar hormones at that) are present in much higher concentration. Sensing this sudden increase, it will shut down its own activities in the production of testosterone to avoid extreme excessive levels. There are numerous processes that take place in order to do this. One of the most notable however include the decrease in the production of both follicle stimulating hormone (FSH) and luteinizing hormone (LH) – two hormones that is released by the pituitary gland. These hormones are crucial in stimulating the testes to release testosterone as well as in the production of sperm cells.

AAS intake ensures enough level of testosterone in the body. It appeared okay as you only need to switch off the natural production of testosterone and your body’s testosterone needs has been replaced by what was produced by the AAS.  Unfortunately, this synthetic advantage comes with a bigger problem – infertility.

Your testes do not work simply to produce testosterone. The Leydig cells present on your testes actually release testosterone after it was stimulated by LH. Testosterone is released near your sertoli cells. When these sertoli cells sense that there is an increased level of testosterone, they are triggered to act and stimulate the release of mature sperm cells through a process known as spermatogenesis. Unfortunately for all AAS users, simply increasing the testosterone levels in the blood could not mimic this important activity for human race to continue. Thus, AAS administration will shut down the natural production of testosterone, slow down and end up preventing the production and maturation of sperm cells. Infertility occurs as a direct side effect of AAS use.

How do HMG works?

HMG works similarly with HCG wherein it stimulates the Leydig cells to naturally produce testosterone thereby restoring fertility. What makes HMG unique and more desirable is the fact that it contains the actual, natural LH instead of just mimicking its actions. More importantly, it contains purified FSH. It has both these crucial hormones thereby enabling its users to naturally produce testosterone from the Leydig cells. In the end, HMG is able to promote maturation and production of sperm cells. Since it is able to help with the production of testosterone, it could also aide in the development of muscle mass and strength while improving athletic performance.

Is HMG effective?

Despite the lack of clinical trials to evaluate the efficiency of HMG, anecdotal evidence show that it is effective in restoring fertility, natural testosterone levels and normal spermatogenesis. Evidence from some clinical studies has also shown substantial and promising results. It is important to note however that every individual has unique reactions to HMG. It may be effective for you but it can be useless for another individual. With all the positive reviews about it and how it surpasses the efficiency of human chorionic gonadotropin (HCG) hormone, HMG is definitely worth a try.

How much HMG should you take?

Research has shown that injecting yourself with HMG three times a week with a recommended dose of 75 IU to 150 IU is enough to receive its beneficial effects. Experts however recommend to use 75 IU every 2 days for optimal effects. It has not been proven that higher dosage intake can improve the efficiency of HMG.


HMG is available in vials and different doses in international units (IU). You will need to incorporate a sterile solution on the HMG vial before injecting it to yourself. Please ensure that you buy HMG from trustworthy and respectable sellers.